about
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosisBiophysical and computational methods to analyze amino acid interaction networks in proteinsL2′ loop is critical for caspase-7 active site formationThe crystal structure of caspase-6, a selective effector of axonal degenerationThermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3.Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxinsZinc-mediated Allosteric Inhibition of Caspase-6Allosteric Inhibition of a Zinc-Sensing Transcriptional Repressor: Insights into the Arsenic Repressor (ArsR) FamilyStructural snapshots reveal distinct mechanisms of procaspase-3 and -7 activationAllosteric modulation of caspase 3 through mutagenesisAllosteric peptides bind a caspase zymogen and mediate caspase tetramerizationTunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selectionProtein sectors: evolutionary units of three-dimensional structureThe overlap of small molecule and protein binding sites within families of protein structuresRigid Residue Scan Simulations Systematically Reveal Residue Entropic Roles in Protein AllosteryTargeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug DiscoveryTwo-state selection of conformation-specific antibodiesStructure-based predictive models for allosteric hot spots.Allosteric regulation of protease activity by small molecules.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.A bifunctional allosteric site in the dimer interface of procaspase-3A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.Human caspases: activation, specificity, and regulationModifying caspase-3 activity by altering allosteric networks.Small Molecule Active Site Directed Tools for Studying Human CaspasesAllosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoverySmall-Molecule-Induced and Cooperative Enzyme Assembly on a 14-3-3 Scaffold.Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3.A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases.Cholesterol lowering drug may influence cellular immune response by altering MHC II function.The origin of allosteric functional modulation: multiple pre-existing pathways.Dissecting an allosteric switch in caspase-7 using chemical and mutational probesProtein functional landscapes, dynamics, allostery: a tortuous path towards a universal theoretical framework.Current knowledge on procaspase-1 variants with reduced or abrogated enzymatic activity in autoinflammatory disease.Identification of specific tethered inhibitors for caspase-5.Cardiac and skeletal muscles show molecularly distinct responses to cancer cachexia.Prediction of allosteric sites and mediating interactions through bond-to-bond propensities.Allosteric sites can be identified based on the residue-residue interaction energy difference.Solvated dissipative electro-elastic network model of hydrated proteins.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
An Allosteric Circuit in Caspase-1
@ast
An Allosteric Circuit in Caspase-1
@en
An Allosteric Circuit in Caspase-1
@nl
type
label
An Allosteric Circuit in Caspase-1
@ast
An Allosteric Circuit in Caspase-1
@en
An Allosteric Circuit in Caspase-1
@nl
prefLabel
An Allosteric Circuit in Caspase-1
@ast
An Allosteric Circuit in Caspase-1
@en
An Allosteric Circuit in Caspase-1
@nl
P2093
P2860
P3181
P1476
An Allosteric Circuit in Caspase-1
@en
P2093
Debajyoti Datta
James A Wells
Justin M Scheer
Michael J Romanowski
P2860
P304
P3181
P356
10.1016/J.JMB.2008.06.040
P407
P577
2008-09-19T00:00:00Z