Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair - Test2 - elhamkhani - TriplyDB

Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair

Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair

http://www.wikidata.org/entity/Q27651403

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Structural basis of γH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4 Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications BRCT domains: easy as one, two, three A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation γH2A binds Brc1 to maintain genome integrity during S-phase Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1 Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1 Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting Complex The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator Structural Insights into Recognition of MDC1 by TopBP1 in DNA Replication Checkpoint Control Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1 Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1 Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint Mdb1, a fission yeast homolog of human MDC1, modulates DNA damage response and mitotic spindle function Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.Expanding the landscape of chromatin modification (CM)-related functional domains and genes in human.Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization.Yeast DNA ligase IV mutations reveal a nonhomologous end joining function of BRCT1 distinct from XRCC4/Lif1 binding.Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair.Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants Critical Function of γH2A in S-Phase Dimerization Mediated by a Divergent Forkhead-associated Domain Is Essential for the DNA Damage and Spindle Functions of Fission Yeast Mdb1.Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.Brc1 links replication stress response and centromere function.γH2A-binding protein Brc1 affects centromere function in fission yeast Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant.Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining.Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage.Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping.BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX.

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Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair

http://www.wikidata.org/entity/Q27651403

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2008 nî lūn-bûn

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2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2008 թվականի օգոստոսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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Structural and functional anal ...... ignaling and DNA damage repair

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Structural and functional anal ...... ignaling and DNA damage repair

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Structural and functional anal ...... ignaling and DNA damage repair

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Structural and functional anal ...... ignaling and DNA damage repair

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Structural and functional anal ...... ignaling and DNA damage repair

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Structural and functional anal ...... ignaling and DNA damage repair

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Structural and functional anal ...... ignaling and DNA damage repair

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Structural and functional anal ...... ignaling and DNA damage repair

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Structural and functional anal ...... ignaling and DNA damage repair

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Structural and functional anal ...... ignaling and DNA damage repair

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Andrew S Doré

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Felicity Z Watts

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Jenny C Y Ho

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Konstantinos Nestoras

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Laurence H Pearl

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Mairi L Kilkenny

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S Mark Roe

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Crystal structure of the nucleosome core particle at 2.8 A resolution

MDC1 is a mediator of the mammalian DNA damage checkpoint

The BRCT domain is a phospho-protein binding domain

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

Chk2 activates E2F-1 in response to DNA damage

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor.

DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe

Human CtIP promotes DNA end resection

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scholarly article

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10.1101/GAD.472808

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15

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22

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2008-08-01T00:00:00Z

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18676809

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2492745

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