Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2 - Test2 - elhamkhani - TriplyDB

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

http://www.wikidata.org/entity/Q27657715

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TRIM5 is an innate immune sensor for the retrovirus capsid lattice Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 NF-κB, the first quarter-century: remarkable progress and outstanding questions When ubiquitin meets NF-κB: a trove for anti-cancer drug development Getting TRAIL back on track for cancer therapy Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation Regulation of tumour necrosis factor signalling: live or let die TRAIL activates JNK and NF-κB through RIP1-dependent and -independent pathways Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.The API2-MALT1 fusion exploits TNFR pathway-associated RIP1 ubiquitination to promote oncogenic NF-κB signaling.A novel TNF receptor-associated factor 6 binding domain mediates NF-kappa B signaling by the common cytokine receptor beta subunit.Mutational analysis of TRAF6 reveals a conserved functional role of the RING dimerization interface and a potentially necessary but insufficient role of RING-dependent TRAF6 polyubiquitination towards NF-κB activation Contribution of E3-ubiquitin ligase activity to HIV-1 restriction by TRIM5alpha(rh): structure of the RING domain of TRIM5alpha.Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation.Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway.TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1 TRAF2 exerts opposing effects on basal and TNFα-induced activation of the classic IKK complex in hematopoietic cells in mice Molecular basis of NF-κB signaling TRAF molecules in cell signaling and in human diseases TRAF4, at the Crossroad between Morphogenesis and Cancer.Structural basis of signal transduction in the TNF receptor superfamily TNFR1 signaling kinetics: spatiotemporal control of three phases of IKK activation by posttranslational modification.Molecular cell death platforms and assemblies.Structural studies of NF-κB signaling.T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy.Ubiquitination in signaling to and activation of IKK.Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily Regulation of NF-κB by TNF family cytokines.Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.Deciphering CD137 (4-1BB) signaling in T-cell costimulation for translation into successful cancer immunotherapy.Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed IκB kinase activation.IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1/FADD/caspase-8 complexes.c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.The Role of Ubiquitination in TWEAK-Stimulated Signaling.NF-kappaB signal triggering and termination by tumor necrosis factor receptor 2.USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation.TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis.The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1.

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P2860

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

http://www.wikidata.org/entity/Q27657715

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

@ast

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

@en

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

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type

label

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

@ast

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

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Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

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prefLabel

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

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Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

@en

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

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Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

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Betty Lamothe

http://www.w3.org/2001/XMLSchema#string

Bryant G Darnay

http://www.w3.org/2001/XMLSchema#string

Hao Wu

http://www.w3.org/2001/XMLSchema#string

Qian Yin

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P2860

A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction

The RAG1 N-terminal domain is an E3 ubiquitin ligase

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

Distinct molecular mechanism for initiating TRAF6 signalling

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination

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10558-67

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scholarly article

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10.1021/BI901462E

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44

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48

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2009-11-10T00:00:00Z

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26877669

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19810754

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2830148

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