Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.
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A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cellsCellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicityOvercoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)Inhibitor of apoptosis proteins as therapeutic targets in multiple myeloma.EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells.Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice.The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced ApoptosisHAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerizationInhibitor of apoptosis proteins as intracellular signaling intermediates.An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics.Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death.Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity.Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents.Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs)IAPs: guardians of RIPK1IAPS and ubiquitylation.Nutrient availability links mitochondria, apoptosis, and obesity.Role of the TWEAK-Fn14-cIAP1-NF-κB Signaling Axis in the Regulation of Myogenesis and Muscle HomeostasisIAP Antagonists Enhance Apoptotic Response to Enzalutamide in Castration-Resistant Prostate Cancer Cells via Autocrine TNF-α Signaling.Effects of physiological and synthetic IAP antagonism on c-IAP-dependent signaling.Anti-Apoptotic Signature in Thymic Squamous Cell Carcinomas - Functional Relevance of Anti-Apoptotic BIRC3 Expression in the Thymic Carcinoma Cell Line 1889c.Degradation of cIAPs contributes to hepatocyte lipoapoptosis.SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesotheliomaBivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-κB signaling by degrading TRAF2-associated cIAP1 in cancer cells.Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice.CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex.Response to Heard et al.Developmental Therapeutics in Myeloproliferative Neoplasms.RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice.Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death.Proteasome inhibition blocks necroptosis by attenuating death complex aggregation.Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization.Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists
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P2860
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.
@en
type
label
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.
@en
prefLabel
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.
@en
P2093
P2860
P356
P1476
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.
@en
P2093
P2860
P2888
P304
P356
10.1038/CDD.2011.10
P577
2011-02-18T00:00:00Z
P5875
P6179
1009171768