IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
about
An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitinationSmac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosisIAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradationRIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosisTWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcriptionIdentification of a novel protein kinase Cδ-Smac complex that dissociates during paclitaxel-induced cell deathcIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoformsRecognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complexARTS and Siah collaborate in a pathway for XIAP degradationThe USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2OTUB1 modulates c-IAP1 stability to regulate signalling pathwaysPellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-αcIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)Is NF-kappaB a good target for cancer therapy? Hopes and pitfallsc-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activationMany stimuli pull the necrotic trigger, an overviewDrugging the undruggables: exploring the ubiquitin system for drug developmentTargeting Cell Survival Proteins for Cancer Cell DeathBacteria-host relationship: ubiquitin ligases as weapons of invasionDeath in the fast lane: what's next for necroptosis?DED or alive: assembly and regulation of the death effector domain complexesNF-κB, the first quarter-century: remarkable progress and outstanding questionsInhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammationWhen ubiquitin meets NF-κB: a trove for anti-cancer drug developmentFueling the flames: Mammalian programmed necrosis in inflammatory diseasesThe two faces of receptor interacting protein kinase-1Small-molecule SMAC mimetics as new cancer therapeuticsIAPs: a central element in the NF-κB activating signaling pathwayTargeting the apoptosis pathway in hematologic malignanciesNon-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple JuncturesRIPK-dependent necrosis and its regulation by caspases: a mystery in five actsProgrammed necrosis in the cross talk of cell death and inflammationLinear ubiquitination signals in adaptive immune responsesMinnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivocIAP-1 controls innate immunity to C. pneumoniae pulmonary infectionInteraction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein † ‡Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitmentConformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind LigandsStructural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2
P2860
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P2860
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
IAP antagonists induce autoubi ...... d TNFalpha-dependent apoptosis
@ast
IAP antagonists induce autoubi ...... d TNFalpha-dependent apoptosis
@en
IAP antagonists induce autoubi ...... d TNFalpha-dependent apoptosis
@nl
type
label
IAP antagonists induce autoubi ...... d TNFalpha-dependent apoptosis
@ast
IAP antagonists induce autoubi ...... d TNFalpha-dependent apoptosis
@en
IAP antagonists induce autoubi ...... d TNFalpha-dependent apoptosis
@nl
prefLabel
IAP antagonists induce autoubi ...... d TNFalpha-dependent apoptosis
@ast
IAP antagonists induce autoubi ...... d TNFalpha-dependent apoptosis
@en
IAP antagonists induce autoubi ...... d TNFalpha-dependent apoptosis
@nl
P2093
P3181
P1433
P1476
IAP antagonists induce autoubi ...... d TNFalpha-dependent apoptosis
@en
P2093
Anna V Fedorova
Domagoj Vucic
Eugene Varfolomeev
Heidi J A Wallweber
Jasmin N Dynek
John A Flygare
Kerry Zobel
Kurt Deshayes
Linda O Elliott
Nobuhiko Kayagaki
P304
P3181
P356
10.1016/J.CELL.2007.10.030
P407
P577
2007-11-01T00:00:00Z