Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing - Test2 - elhamkhani - TriplyDB

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

http://www.wikidata.org/entity/Q27671696

about

Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10 HIV-1 superinfection in women broadens and strengthens the neutralizing antibody response A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union Increasing the potency and breadth of an HIV antibody by using structure-based rational design Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals New approaches to understanding the immune response to vaccination and infection Advances in structure-based vaccine design Structural insights on the role of antibodies in HIV-1 vaccine and therapy A Blueprint for HIV Vaccine Discovery HIV-1 neutralizing antibodies: understanding nature's pathways Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination Host-pathogen interaction in HIV infection HIV-1 envelope glycoprotein structure Antibodies in HIV-1 vaccine development and therapy HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design Development of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection Designing vaccines for the twenty-first century society Mixed adjuvant formulations reveal a new combination that elicit antibody response comparable to Freund's adjuvants Shaping T cell - B cell collaboration in the response to human immunodeficiency virus type 1 envelope glycoprotein gp120 by peptide priming HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunization ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design Deconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and Immunity Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield Broad and potent neutralization of HIV-1 by a gp41-specific human antibody Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04 Viral Escape from Neutralizing Antibodies in Early Subtype A HIV-1 Infection Drives an Increase in Autologous Neutralization Breadth A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16 Interfacial Cavity Filling To Optimize CD4–Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175

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Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

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description

2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Charlene Wang

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John A Crump

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P2860

Dendroscope: An interactive viewer for large phylogenetic trees

MUSCLE: a multiple sequence alignment method with reduced time and space complexity

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Electrostatics of nanosystems: application to microtubules and the ribosome

MUSCLE: multiple sequence alignment with high accuracy and high throughput

IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis

Structural definition of a conserved neutralization epitope on HIV-1 gp120

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

pdb-care (PDB carbohydrate residue check): a program to support annotation of complex carbohydrate structures in PDB files

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