about
Chimpanzee Adenovirus Vector Ebola Vaccine — Preliminary ReportThe gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytesPolyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individualsGene transfer in humans using a conditionally replicating lentiviral vectorBroadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral SerotypeWhich New Health Technologies Do We Need to Achieve an End to HIV/AIDS?Antibody responses to envelope glycoproteins in HIV-1 infectionHIV-1 neutralizing antibodies: understanding nature's pathwaysA Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial VirusStructure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding siteVaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding SiteHIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunizationStructure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial VirusA West Nile Virus DNA Vaccine Induces Neutralizing Antibody in Healthy Adults during a Phase 1 Clinical TrialStructural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 DonorsCrystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 EnvMaturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic AntibodyStructure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9Co-evolution of a broadly neutralizing HIV-1 antibody and founder virusDevelopmental pathway for potent V1V2-directed HIV-neutralizing antibodiesVaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A VirusesStructures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine designOptimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based DesignStructural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep SequencingBroad and potent neutralization of HIV-1 by a gp41-specific human antibodyOuter Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic CharacterizationUnliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loopsStructural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry InhibitorsHeavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding SitesMultidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class AntibodiesStructural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptorDelineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization
P50
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P50
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John R Mascola
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John R Mascola
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John R Mascola
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John R Mascola
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John R Mascola
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John R Mascola
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John R Mascola
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John R Mascola
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John R Mascola
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John R Mascola
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John R Mascola
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