Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography
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Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallographyBinding to large enzyme pockets: small-molecule inhibitors of trypanothione reductaseThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsIn-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plantsGenetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme.In silico work flow for scaffold hopping in LeishmaniaLocating sweet spots for screening hits and evaluating pan-assay interference filters from the performance analysis of two lead-like librariesInduction of oxidative stress in Trypanosoma brucei by the antitrypanosomal dihydroquinoline OSU-40.Drug discovery and human African trypanosomiasis: a disease less neglected?Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.Thioredoxin reductase and its inhibitors.Molecular recognition in chemical and biological systems.Polyamine-trypanothione pathway: an update.Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.In silico structural characterization of protein targets for drug development against Trypanosoma cruzi.Inhibitors of Trypanosoma brucei trypanothione reductase: comparative molecular field analysis modeling and structural basis for selective inhibition.Syntheses of 3,4- and 1,4-dihydroquinazolines from 2-aminobenzylamine.Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei.Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides.Access to Chiral Hydropyrimidines through Palladium-Catalyzed Asymmetric Allylic C-H Amination.Solid state structure and solution thermodynamics of three-centered hydrogen bonds (O∙∙∙H∙∙∙O) using N-(2-benzoyl-phenyl) oxalyl derivatives as model compounds.Synthesis of dihydroquinazolines from 2-aminobenzylamine: aryl derivatives with electron-withdrawing groupsComparison of hydrocarbon-and lactam-bridged cyclic peptides as dimerization inhibitors of Leishmania infantum trypanothione reductase
P2860
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P2860
Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Dihydroquinazolines as a Novel ...... ode by Protein Crystallography
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Dihydroquinazolines as a Novel ...... ode by Protein Crystallography
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Dihydroquinazolines as a Novel ...... ode by Protein Crystallography
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type
label
Dihydroquinazolines as a Novel ...... ode by Protein Crystallography
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Dihydroquinazolines as a Novel ...... ode by Protein Crystallography
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Dihydroquinazolines as a Novel ...... ode by Protein Crystallography
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Dihydroquinazolines as a Novel ...... ode by Protein Crystallography
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Dihydroquinazolines as a Novel ...... ode by Protein Crystallography
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Dihydroquinazolines as a Novel ...... ode by Protein Crystallography
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P2093
P2860
P50
P356
P1476
Dihydroquinazolines as a Novel ...... ode by Protein Crystallography
@en
P2093
Deuan C Jones
Ian P Street
Julie A Frearson
Magnus S Alphey
Stephen Patterson
P2860
P304
P356
10.1021/JM200312V
P407
P577
2011-10-13T00:00:00Z