Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family
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Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused DerivativesBromodomain proteins in HIV infectionOptimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain LigandsDiscovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual ScreeningDiscovery, Design, and Optimization of Isoxazole Azepine BET InhibitorsDifferent orientations of low-molecular-weight fragments in the binding pocket of a BRD4 bromodomainTargeting bromodomains: epigenetic readers of lysine acetylationTargeting BET bromodomains for cancer treatmentGeneration of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia TherapyDrug Discovery Targeting Bromodomain-Containing Protein 4.Privileged diazepine compounds and their emergence as bromodomain inhibitors.Small-molecular modulators of cancer-associated epigenetic mechanisms.A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesisBromodomain inhibitors regulate the C9ORF72 locus in ALSMapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling.Accurate calculation of the absolute free energy of binding for drug molecules.Development of neurodevelopmental disorders: a regulatory mechanism involving bromodomain-containing proteinsThe bromodomain interaction module.Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.Bromodomains and their pharmacological inhibitors.Inhibition of bromodomain and extra-terminal proteins (BET) as a potential therapeutic approach in haematological malignancies: emerging preclinical and clinical evidence.Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.Attach-Pull-Release Calculations of Ligand Binding and Conformational Changes on the First BRD4 Bromodomain.The solvation structure of alprazolam.Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology.Protein-protein interactions: detection, reliability assessment and applications.Bromodomain and extra-terminal (BET) family proteins: New therapeutic targets in major diseases.A chemical probe toolbox for dissecting the cancer epigenome.Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL and induce apoptosis in human oral tumor cells.HIV-1 Tat Binding to PCAF Bromodomain: Structural Determinants from Computational Methods.9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomainSelective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations.Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations.Stimulation of Hepatic Apolipoprotein A-I Production by Novel Thieno-Triazolodiazepines: Roles of the Classical Benzodiazepine Receptor, PAF Receptor, and Bromodomain Binding.2-Amino-N'-phenyl-benzohydrazide.Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors.In silico design and bioevaluation of selective benzotriazepine BRD4 inhibitors with potent antiosteoclastogenic activity.A computational insight into binding modes of inhibitors XD29, XD35, and XD28 to bromodomain-containing protein 4 based on molecular dynamics simulations.
P2860
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P2860
Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Benzodiazepines and benzotriaz ...... bromodomains of the BET family
@ast
Benzodiazepines and benzotriaz ...... bromodomains of the BET family
@en
Benzodiazepines and benzotriaz ...... bromodomains of the BET family
@nl
type
label
Benzodiazepines and benzotriaz ...... bromodomains of the BET family
@ast
Benzodiazepines and benzotriaz ...... bromodomains of the BET family
@en
Benzodiazepines and benzotriaz ...... bromodomains of the BET family
@nl
prefLabel
Benzodiazepines and benzotriaz ...... bromodomains of the BET family
@ast
Benzodiazepines and benzotriaz ...... bromodomains of the BET family
@en
Benzodiazepines and benzotriaz ...... bromodomains of the BET family
@nl
P2093
P2860
P50
P3181
P1476
Benzodiazepines and benzotriaz ...... bromodomains of the BET family
@en
P2093
Franz Bracher
Marco Keller
Matthias Wrobel
P2860
P304
P3181
P356
10.1016/J.BMC.2011.10.080
P407
P577
2012-03-15T00:00:00Z