UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation - Test2 - elhamkhani - TriplyDB

UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation

UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation

http://www.wikidata.org/entity/Q34590516

about

PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo Covalent protein modification with ISG15 via a conserved cysteine in the hinge region High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15.Post-translational modifications of PML: consequences and implications.UBE1L causes lung cancer growth suppression by targeting cyclin D1.Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification.Emerging roles for immunomodulatory functions of free ISG15.Targeting promyelocytic leukemia protein: a means to regulating PML nuclear bodies The ISG15-specific protease USP18 regulates stability of PTEN.Interferon-stimulated gene 15 and the protein ISGylation system.Regulation of the tumor suppressor PML by sequential post-translational modifications.Potential biomarkers and latent pathways for vasculitis based on latent pathway identification analysis.Synergistic targeted therapy for acute promyelocytic leukaemia: a model of translational research in human cancer.PML: An emerging tumor suppressor and a target with therapeutic potential.PML: Regulation and multifaceted function beyond tumor suppression.Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target.Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.

P2860

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P2860

UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation

http://www.wikidata.org/entity/Q34590516

description

2008 nî lūn-bûn

@nan

2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation

@en

UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation

@nl

type

label

UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation

@en

UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation

@nl

prefLabel

UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation

@en

UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation

@nl

P1433

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P1476

Q34590516-9B91CF1F-2275-461A-8691-972C95E84098

P2093

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P2860

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P304

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P31

Q34590516-0557C873-C5EB-437E-841A-0A23D4EE0688

P356

Q34590516-EB0F817B-19A3-43F8-8837-238A59A95C4D

P433

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P478

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P577

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P698

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P932

Q34590516-4A424066-2423-4037-A745-C6C51F81231F

P356

1535-7163.MCT-07-0515

P1433

Molecular Cancer Therapeutics

P1476

UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation

@en

P2093

Ethan Dmitrovsky

http://www.w3.org/2001/XMLSchema#string

Ian Pitha-Rowe

http://www.w3.org/2001/XMLSchema#string

Qing Feng

http://www.w3.org/2001/XMLSchema#string

Sarah J Freemantle

http://www.w3.org/2001/XMLSchema#string

Steven Blumen

http://www.w3.org/2001/XMLSchema#string

Sumit J Shah

http://www.w3.org/2001/XMLSchema#string

Sutisak Kitareewan

http://www.w3.org/2001/XMLSchema#string

P2860

UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity

UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia

Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein

The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein

Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway.

UBP43 (USP18) specifically removes ISG15 from conjugated proteins.

The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase.

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML

Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2

Covalent modification of PML by the sentrin family of ubiquitin-like proteins

P304

905-914

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1158/1535-7163.MCT-07-0515

http://www.w3.org/2001/XMLSchema#string

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P577

2008-04-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

18413804

http://www.w3.org/2001/XMLSchema#string

P932

2597092

http://www.w3.org/2001/XMLSchema#string