Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.
about
Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathwaysp53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylaseSir2-independent life span extension by calorie restriction in yeastLife span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9Increased life span due to calorie restriction in respiratory-deficient yeastReversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damageStructural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylasesDietary interventions to extend life span and health span based on calorie restrictionLessons on longevity from budding yeastNutrient-sensitive mitochondrial NAD+ levels dictate cell survivalSIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus.Biochemical effects of SIRT1 activatorsSmall molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetesThe neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodiesResveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life spanNicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotauCalorie restriction and the exercise of chromatinCircadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesisHormonal control of androgen receptor function through SIRT1Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1Critical roles for a genetic code alteration in the evolution of the genus CandidaSirtuin 1 and sirtuin 3: physiological modulators of metabolismSirtuins as regulators of metabolism and healthspanMetabolic modulation of chromatin: implications for DNA repair and genomic integrityTargeting sirtuin 1 to improve metabolism: all you need is NAD(+)?The role of mammalian sirtuins in the regulation of metabolism, aging, and longevityNAD+ as a signaling molecule modulating metabolismSirtuins in epigenetic regulationPeroxisomes take shapeThe evolutionary portrait of metazoan NAD salvageStructural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 EnzymesCrystal structure of the yeast nicotinamidase Pnc1pRestructuring of the dinucleotide-binding fold in an NADP(H) sensor proteinHigh-Resolution Crystal Structures of Streptococcus pneumoniae Nicotinamidase with Trapped Intermediates Provide Insights into the Catalytic Mechanism and Inhibition by Aldehydes,The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in YeastThe Leishmania nicotinamidase is essential for NAD+ production and parasite proliferationStructural and Kinetic Isotope Effect Studies of Nicotinamidase (Pnc1) from Saccharomyces cerevisiaeMitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications
P2860
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P2860
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Nicotinamide and PNC1 govern l ...... n in Saccharomyces cerevisiae.
@ast
Nicotinamide and PNC1 govern l ...... n in Saccharomyces cerevisiae.
@en
Nicotinamide and PNC1 govern l ...... n in Saccharomyces cerevisiae.
@nl
type
label
Nicotinamide and PNC1 govern l ...... n in Saccharomyces cerevisiae.
@ast
Nicotinamide and PNC1 govern l ...... n in Saccharomyces cerevisiae.
@en
Nicotinamide and PNC1 govern l ...... n in Saccharomyces cerevisiae.
@nl
prefLabel
Nicotinamide and PNC1 govern l ...... n in Saccharomyces cerevisiae.
@ast
Nicotinamide and PNC1 govern l ...... n in Saccharomyces cerevisiae.
@en
Nicotinamide and PNC1 govern l ...... n in Saccharomyces cerevisiae.
@nl
P2093
P2860
P3181
P356
P1433
P1476
Nicotinamide and PNC1 govern l ...... n in Saccharomyces cerevisiae.
@en
P2093
Jason G Wood
Kevin J Bitterman
Oliver Medvedik
Rozalyn M Anderson
P2860
P2888
P3181
P356
10.1038/NATURE01578
P407
P577
2003-05-08T00:00:00Z
P5875
P6179
1046374959