Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells
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The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) PhenotypeATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichmentAlternative lengthening of telomeres can be maintained by preferential elongation of lagging strands.miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an "ALT-like" phenotype in diffuse malignant peritoneal mesothelioma cells.Detection of ATRX and IDH1-R132H immunohistochemistry in the progression of 211 paired gliomasATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma.Stop pulling my strings - what telomeres taught us about the DNA damage response.ATRX and DAXX: Mechanisms and Mutations.Systematic analysis of telomere length and somatic alterations in 31 cancer types.Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition.The Role of ATRX in Glioma Biology.MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption.Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2.Loss of Tumor Suppressor STAG2 Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells.Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes.Telomere chromatin establishment and its maintenance during mammalian development.dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres.Inherited germline ATRX mutation in two brothers with ATR-X syndrome and osteosarcoma.Reconstructing the molecular life history of gliomas.Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling.Mutant ATRX: uncovering a new therapeutic target for glioma.
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P2860
Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells
description
2015 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2015
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im September 2015 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2015/09/14)
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vědecký článek publikovaný v roce 2015
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wetenschappelijk artikel (gepubliceerd op 2015/09/14)
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наукова стаття, опублікована у вересні 2015
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مقالة علمية (نشرت في 14-9-2015)
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name
Loss of ATRX Suppresses Resolu ...... ombination in ALT Cancer Cells
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Loss of ATRX Suppresses Resolu ...... ombination in ALT Cancer Cells
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Loss of ATRX Suppresses Resolu ...... ombination in ALT Cancer Cells
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label
Loss of ATRX Suppresses Resolu ...... ombination in ALT Cancer Cells
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Loss of ATRX Suppresses Resolu ...... ombination in ALT Cancer Cells
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Loss of ATRX Suppresses Resolu ...... ombination in ALT Cancer Cells
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prefLabel
Loss of ATRX Suppresses Resolu ...... ombination in ALT Cancer Cells
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Loss of ATRX Suppresses Resolu ...... ombination in ALT Cancer Cells
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Loss of ATRX Suppresses Resolu ...... ombination in ALT Cancer Cells
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P2860
P921
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Loss of ATRX Suppresses Resolu ...... ombination in ALT Cancer Cells
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P2093
Mahesh Ramamoorthy
Susan Smith
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P304
P3181
P356
10.1016/J.CCELL.2015.08.003
P577
2015-09-14T00:00:00Z