The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
about
Unwinding and rewinding: double faces of helicase?RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progressionA critical role for TPP1 and TIN2 interaction in high-order telomeric complex assemblyGenome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cellsWRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shorteningPOT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substratesSIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatinRoles of Werner syndrome protein in protection of genome integrityModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesRoles of RECQ helicases in recombination based DNA repair, genomic stability and agingRecBCD enzyme and the repair of double-stranded DNA breaksIdentification of a novel, widespread, and functionally important PCNA-binding motifHuman RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication forkHuman premature aging, DNA repair and RecQ helicasesOxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variantEvidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.Disease-causing missense mutations in human DNA helicase disordersThe role of RecQ helicases in non-homologous end-joiningRoles of DNA helicases in the maintenance of genome integrityTelomere shortening in human diseasesc-Myc accelerates S-phase and requires WRN to avoid replication stressSLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with TelomeresRecQ helicases in DNA double strand break repair and telomere maintenance.Yeast Pif1 accelerates annealing of complementary DNA strands.Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1Epigenetic inactivation of the premature aging Werner syndrome gene in human cancerThe Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradationAssociation of BLM and BRCA1 during Telomere Maintenance in ALT CellsWRN loss induces switching of telomerase-independent mechanisms of telomere elongationThe DNA structure and sequence preferences of WRN underlie its function in telomeric recombination eventsRECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenanceTelomeres and human disease: ageing, cancer and beyondExpression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.Unwinding protein complexes in ALTernative telomere maintenance.Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicaseThe origin of oxidized guanine resolves the puzzle of oxidation-induced telomere-length alterations.Mechanism of Werner DNA helicase: POT1 and RPA stimulates WRN to unwind beyond gaps in the translocating strand.Replication protein A stimulates the Werner syndrome protein branch migration activity.Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN.
P2860
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P2860
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
description
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Juni 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/06/18)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/06/18)
@nl
наукова стаття, опублікована в червні 2004
@uk
مقالة علمية (نشرت في 18-6-2004)
@ar
name
The Werner syndrome helicase a ...... ner regulated by TRF1 and TRF2
@ast
The Werner syndrome helicase a ...... ner regulated by TRF1 and TRF2
@en
The Werner syndrome helicase a ...... ner regulated by TRF1 and TRF2
@nl
type
label
The Werner syndrome helicase a ...... ner regulated by TRF1 and TRF2
@ast
The Werner syndrome helicase a ...... ner regulated by TRF1 and TRF2
@en
The Werner syndrome helicase a ...... ner regulated by TRF1 and TRF2
@nl
prefLabel
The Werner syndrome helicase a ...... ner regulated by TRF1 and TRF2
@ast
The Werner syndrome helicase a ...... ner regulated by TRF1 and TRF2
@en
The Werner syndrome helicase a ...... ner regulated by TRF1 and TRF2
@nl
P2093
P921
P3181
P1433
P1476
The Werner syndrome helicase a ...... ner regulated by TRF1 and TRF2
@en
P2093
Alfred May
Jesper Graakjaer
Lale Dawut
Michael M. Seidman
Patricia L. Opresko
Per Bruheim
Steen Kølvraa
Vilhem A. Bohr
P304
P3181
P356
10.1016/J.MOLCEL.2004.05.023
P577
2004-06-18T00:00:00Z