POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
about
Thermodynamic characterization of specific interactions between the human Lon protease and G-quartet DNAShelterin complex and associated factors at human telomeresRoles of Werner syndrome protein in protection of genome integrityRoles of RECQ helicases in recombination based DNA repair, genomic stability and agingHuman premature aging, DNA repair and RecQ helicasesG-quadruplexes and their regulatory roles in biologyTelomere shortening in human diseasesRecQ helicases in DNA double strand break repair and telomere maintenance.Yeast Pif1 accelerates annealing of complementary DNA strands.Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1Genetic determinants of human health span and life span: progress and new opportunitiesThe Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradationAssociation of BLM and BRCA1 during Telomere Maintenance in ALT CellsWRN loss induces switching of telomerase-independent mechanisms of telomere elongationThe DNA structure and sequence preferences of WRN underlie its function in telomeric recombination eventsBLM helicase facilitates telomere replication during leading strand synthesis of telomeresRECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenanceTopoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.Unwinding protein complexes in ALTernative telomere maintenance.Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere lossArabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance.Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicaseMechanism of Werner DNA helicase: POT1 and RPA stimulates WRN to unwind beyond gaps in the translocating strand.Replication protein A stimulates the Werner syndrome protein branch migration activity.Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN.Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activityHuman RECQL1 participates in telomere maintenanceDistinct roles of RECQ1 in the maintenance of genomic stability.Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.Hydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cellsSingle molecule studies of physiologically relevant telomeric tails reveal POT1 mechanism for promoting G-quadruplex unfolding.Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Structural insights into G-quadruplexes: towards new anticancer drugs.Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loopsHyper telomere recombination accelerates replicative senescence and may promote premature aging.Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination.Telomeres: structures in need of unwinding.Telomere profiling: toward glioblastoma personalized medicine.Telomere-regulating genes and the telomere interactome in familial cancers.
P2860
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P2860
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@ast
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@en
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@en-gb
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@nl
type
label
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@ast
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@en
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@en-gb
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@nl
prefLabel
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@ast
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@en
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@en-gb
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@nl
P2093
P2860
P50
P356
P1476
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
@en
P2093
Ian D Hickson
Penelope A Mason
Vilhelm A Bohr
P2860
P304
P356
10.1074/JBC.M505211200
P407
P577
2005-09-16T00:00:00Z