Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase
about
Shelterin complex and associated factors at human telomeresRoles of Werner syndrome protein in protection of genome integrityRoles of RECQ helicases in recombination based DNA repair, genomic stability and agingTelomere shortening in human diseasesRecQ helicases in DNA double strand break repair and telomere maintenance.Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradationReplication protein A stimulates the Werner syndrome protein branch migration activity.Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN.The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress.DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.Single molecule studies of physiologically relevant telomeric tails reveal POT1 mechanism for promoting G-quadruplex unfolding.POT1-TPP1 regulates telomeric overhang structural dynamics.Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loopsTelomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro.Human RecQ helicases in DNA repair, recombination, and replication.Telomeres do the (un)twist: helicase actions at chromosome termini.DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation.Single-molecule studies reveal reciprocating of WRN helicase core along ssDNA during DNA unwinding.Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.Molecular mechanisms by which oxidative DNA damage promotes telomerase activity.
P2860
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P2860
Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Mechanism and substrate specif ...... f the Werner syndrome helicase
@ast
Mechanism and substrate specif ...... f the Werner syndrome helicase
@en
type
label
Mechanism and substrate specif ...... f the Werner syndrome helicase
@ast
Mechanism and substrate specif ...... f the Werner syndrome helicase
@en
prefLabel
Mechanism and substrate specif ...... f the Werner syndrome helicase
@ast
Mechanism and substrate specif ...... f the Werner syndrome helicase
@en
P2860
P356
P1476
Mechanism and substrate specif ...... f the Werner syndrome helicase
@en
P2093
Gregory Sowd
P2860
P304
P356
10.1093/NAR/GKN385
P407
P577
2008-06-25T00:00:00Z