Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
about
Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygenThe peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stabilityFactor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domainsStudies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assayTargeting Protein-Protein Interactions in the HIF SystemHypoxia and metabolic adaptation of cancer cellsAscorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progressionEpigenetic regulation by histone demethylases in hypoxiaTo breathe or not to breathe: the haematopoietic stem/progenitor cells dilemmaAsparagine beta-hydroxylation stabilizes the ankyrin repeat domain foldQuantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase InhibitorsDisruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activityInhibition of 2-oxoglutarate dependent oxygenasesDistribution and prediction of catalytic domains in 2-oxoglutarate dependent dioxygenases.Determination and comparison of specific activity of the HIF-prolyl hydroxylases.Global microRNA depletion suppresses tumor angiogenesis.Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model.Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies.Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lungThe role of hypoxia inducible factor-1 in hepatocellular carcinoma.The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolismFIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells.Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1)Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.Chromatin and oxygen sensing in the context of JmjC histone demethylasesDifferential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitorsReporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.Human high-altitude adaptation: forward genetics meets the HIF pathway.Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases.Oxygen-Dependent Gene Expression in Development and Cancer: Lessons Learned from the Wilms' Tumor Gene, WT1Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cellsThe rate-limiting step of O2 activation in the α-ketoglutarate oxygenase factor inhibiting hypoxia inducible factor.Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo(-/-) mice.A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes.Nothing Iffy about HIF in the Hypothalamus.A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways.
P2860
Q24299724-2228B15A-FA07-4238-8C00-FCCE7E54AAEFQ24299896-8D62B88C-EA40-4D9D-9F6A-F365E4AC552AQ24337743-D623798C-5C22-41F9-9A6D-5CA3889768D2Q24671869-275EBE63-749E-4F0D-9C69-F2F94955077FQ26753176-91E4B0DE-8450-4294-8099-647A4D9A8D60Q26774856-F70B8005-2AB6-43A3-9F26-5145EB17405AQ26822640-C2016684-48CB-44EA-81B0-454C9AE95BEFQ26825704-423E283B-E9AD-4F0F-A4AA-8AEA08A19564Q26825809-8A439B88-A03D-42D7-996A-F3E008490265Q27653157-EB15A310-D35E-4E82-90F5-392817BB6FF1Q27666155-A13081EE-867F-42A9-A6F8-5A0AEAEE2782Q28118969-D8C393BB-2416-455A-962D-BEBDD6D357D9Q28306956-BE05C710-248C-429D-984F-31306D5BCD09Q30525690-AC04A69B-29AF-4929-8882-9154710B0B24Q33292362-65A9DFBB-B274-4175-A4F9-EA37A8002D5EQ33671775-52B7916E-F414-44B1-9DA9-EC0D1B0E2DAFQ33721340-DE0D691E-30C0-4987-A4F4-984C55675C8BQ33725645-DBD804FC-BF37-4F0C-9084-A19DF34E3FBBQ33900675-8B630BAA-7DE4-48B6-B849-9986EFDA0E35Q33914603-DD7EC281-5893-4A79-82F1-7315F85801DAQ33945163-6248F5CF-09D2-46F1-9920-606EF0109A65Q33947033-9B070F06-C9CB-4360-B1A6-C7868C1E4AACQ34001546-ED831034-DA13-4A83-A260-E20FA9F79472Q34009713-2EBFBD5D-0F65-41CB-B306-B4A55D0EE6B9Q34094330-7F763716-CF55-4D95-A7C4-46B4EDE3C960Q34103385-E756D1D0-67A0-41B6-A68E-76AE6239AF63Q34165761-1184848A-AAF9-48FB-AAE1-82E737CB27A1Q34317183-D8FD1FCC-1927-4A6F-BA2C-337DC8384F15Q34360748-A9AD424F-01C3-4757-BC39-8C049A779076Q34465144-89C87633-E171-4A0E-9201-21B5D36CA717Q34482634-F45B5FFB-E8D1-4C23-BAC5-63BAF900804EQ34553660-8B3E5DE8-4C0D-4416-B08A-481FED7EA940Q34617481-C3108C27-5C71-4CC7-80E1-27837F1D8BF5Q34619590-1E4B933F-19D1-4C1D-8DB2-487E9023557CQ34822239-6F69CF64-73DD-40FA-ADBB-D6DF2E668D70Q35084957-DA88304B-7D8A-4C36-B312-13D6B5C18202Q35097231-66D90864-FD0A-4C24-9600-07A641EB735EQ35115789-5FE627B9-DB8C-4A23-B17A-2CBB7E7CD00FQ35129466-03FDA855-52E7-46B8-871A-220126691C8FQ35163974-80502094-AF3B-4AA3-B039-8E3F518D9E13
P2860
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
description
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2004
@ast
im März 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/03/12)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/03/12)
@nl
наукова стаття, опублікована в березні 2004
@uk
name
Catalytic properties of the as ...... e of its prolyl 4-hydroxylases
@ast
Catalytic properties of the as ...... e of its prolyl 4-hydroxylases
@en
Catalytic properties of the as ...... e of its prolyl 4-hydroxylases
@nl
type
label
Catalytic properties of the as ...... e of its prolyl 4-hydroxylases
@ast
Catalytic properties of the as ...... e of its prolyl 4-hydroxylases
@en
Catalytic properties of the as ...... e of its prolyl 4-hydroxylases
@nl
prefLabel
Catalytic properties of the as ...... e of its prolyl 4-hydroxylases
@ast
Catalytic properties of the as ...... e of its prolyl 4-hydroxylases
@en
Catalytic properties of the as ...... e of its prolyl 4-hydroxylases
@nl
P2093
P3181
P356
P1476
Catalytic properties of the as ...... e of its prolyl 4-hydroxylases
@en
P2093
Johanna Myllyharju
Kari I. Kivirikko
Maija Hirsilä
Peppi Koivunen
Volkmar Günzler
P304
P3181
P356
10.1074/JBC.M312254200
P407
P577
2004-03-12T00:00:00Z