A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases
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Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimagingThe blood-brain barrier: bottleneck in brain drug developmentMovement of magnetic nanoparticles in brain tissue: mechanisms and impact on normal neuronal functionQuantitative estimation of pesticide-likeness for agrochemical discoveryBioPhytMol: a drug discovery community resource on anti-mycobacterial phytomolecules and plant extractsPhenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative StressA free energy based computational pathway from chemical templates to lead compounds: a case study of COX-2 inhibitorsMolecular characterization of CYP2B6 substratesDeveloping therapeutic approaches for metachromatic leukodystrophyRational methods for the selection of diverse screening compoundsOff-target effects of psychoactive drugs revealed by genome-wide assays in yeastNovel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnoseOptimal ligand descriptor for pocket recognition based on the Beta-shapeIdentification of New Molecular Entities (NMEs) as Potential Leads against Tuberculosis from Open Source Compound RepositoryGeauxDock: Accelerating Structure-Based Virtual Screening with Heterogeneous ComputingKnowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug DiscoveryExploring the chemical space of influenza neuraminidase inhibitorsProtein structure similarity as guiding principle for combinatorial library design.Compound library development guided by protein structure similarity clustering and natural product structureSite-specific opening of the blood-brain barrier.Ultrasound-induced blood-brain barrier openingOptimization of the ultrasound-induced blood-brain barrier openingProgress and problems in the application of focused ultrasound for blood-brain barrier disruption.A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging.Nanoprobes visualizing gliomas by crossing the blood brain tumor barrier.Feasibility study: refinement of the TTC concept by additional rules based on in silico and experimental data.Identification and preliminary characterization of novel small molecules that inhibit growth of human lung adenocarcinoma cells.Towards Better BBB Passage Prediction Using an Extensive and Curated Data Set.A Data-Driven Approach to Predicting Successes and Failures of Clinical Trials.Recent advances in blood-brain barrier disruption as a CNS delivery strategy.High-throughput assays for promiscuous inhibitors.Novel inhibitors of anthrax edema factor.Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease.Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intronRecent advances in computer-aided drug design.One-pot, three-component, domino Heck-aza-Michael approach to libraries of functionalized 1,1-dioxido-1,2-benzisothiazoline-3-acetic acidsNovel Algorithms for the Identification of Biologically Informative Chemical Diversity Metrics.An integrated drug-likeness study for bicyclic privileged structures: from physicochemical properties to in vitro ADME properties.Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides
P2860
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P2860
A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A knowledge-based approach in ...... zation of known drug databases
@ast
A knowledge-based approach in ...... zation of known drug databases
@en
A knowledge-based approach in ...... zation of known drug databases
@nl
type
label
A knowledge-based approach in ...... zation of known drug databases
@ast
A knowledge-based approach in ...... zation of known drug databases
@en
A knowledge-based approach in ...... zation of known drug databases
@nl
prefLabel
A knowledge-based approach in ...... zation of known drug databases
@ast
A knowledge-based approach in ...... zation of known drug databases
@en
A knowledge-based approach in ...... zation of known drug databases
@nl
P2093
P3181
P356
P1476
A knowledge-based approach in ...... zation of known drug databases
@en
P2093
J J Wendoloski
V N Viswanadhan
P3181
P356
10.1021/CC9800071
P407
P577
1999-01-01T00:00:00Z