Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
about
Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malariaGenome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoaThe transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotesThe transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparumWhat do human parasites do with a chloroplast anyway?Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoeliiGenome sequence of the human malaria parasite Plasmodium falciparumSequencing of the smallest Apicomplexan genome from the human pathogen Babesia microtiThe apicomplexan plastid and its evolutionThe evolution, metabolism and functions of the apicoplastPurification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringaeUse of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparumBiosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritolBiosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thalianaBiosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphateFosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malariaLibrary of Apicomplexan Metabolic Pathways: a manually curated database for metabolic pathways of apicomplexan parasitesA hat trick--Plasmodium, Anopheles and HomoPhylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvumMolecular docking as a popular tool in drug design, an in silico travelAnti-malarial Drug Design by Targeting Apicoplasts: New PerspectivesThe metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium sppGenomics-enabled discovery of phosphonate natural products and their biosynthetic pathwaysApplication of genomics to field investigations of malaria by the international centers of excellence for malaria researchAn FtsH protease is recruited to the mitochondrion of Plasmodium falciparumChemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparumCrystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesisStructure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathwayStructural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductaseStructure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development.Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug developmentCrystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesisBiosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinaseStructures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysisStructure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycinBiosynthesis of isoprenoids in plants: Structure of the 2C-methyl-d-erithrytol 2,4-cyclodiphosphate synthase fromArabidopsis thaliana. Comparison with the bacterial enzymesThe structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discoveryStructure of ( E )-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate PathwayA Structure-Based Approach to Ligand Discovery for 2 C -Methyl- d -erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy †A triclinic crystal form ofEscherichia coli4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure
P2860
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P2860
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
description
1999 nî lūn-bûn
@nan
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
@ast
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
@en
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
@nl
type
label
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
@ast
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
@en
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
@nl
prefLabel
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
@ast
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
@en
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
@nl
P2093
P921
P3181
P1433
P1476
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
@en
P2093
C Weidemeyer
H K Lichtenthaler
I Türbachova
P304
P3181
P356
10.1126/SCIENCE.285.5433.1573
P407
P577
1999-09-03T00:00:00Z