about
Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant miceHaploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communicationSynergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.SHANK1 Deletions in Males with Autism Spectrum DisorderImportance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapsesProgressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteinsPolarized trafficking and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin-adaptor complexesSynaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cellsAbelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formationAutism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neuronsBehavioral phenotypes of genetic mouse models of autism.Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretionCellular and synaptic network defects in autismTherapeutic approaches for shankopathiesStructures of domains I and IV from YbbR are representative of a widely distributed protein familyTandem SAM Domain Structure of Human Caskin1: A Presynaptic, Self-Assembling Scaffold for CASKActin-Dependent Alterations of Dendritic Spine Morphology in ShankopathiesA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Poxviral ankyrin proteinsAutism spectrum disorder in Phelan-McDermid syndrome: initial characterization and genotype-phenotype correlationsAdult restoration of Shank3 expression rescues selective autistic-like phenotypes22q13.3 deletion syndrome: clinical and molecular analysis using array CGHSHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patientsSipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial developmentThe RCC1 domain of protein associated with Myc (PAM) interacts with and regulates KCC2Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1.Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neuronsLoose ligation of the rat sciatic nerve elicits early accumulation of Shank1 protein in the post-synaptic density of spinal dorsal horn neuronsShank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanismShank 2 expression coincides with neuronal differentiation in the developing retinaCommunication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.Sociability and motor functions in Shank1 mutant miceVertebrate tankyrase domain structure and sterile alpha motif (SAM)-mediated multimerizationMembrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel functionSH3 domains: modules of protein-protein interactions.Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.Whole-genome sequencing in multiplex families with psychoses reveals mutations in the SHANK2 and SMARCA1 genes segregating with illness.Ultrastructural analyses in the hippocampus CA1 field in Shank3-deficient mice.Phelan-McDermid Syndrome and SHANK3: Implications for Treatment.
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The Shank family of scaffold proteins
@ast
The Shank family of scaffold proteins
@en
The Shank family of scaffold proteins
@nl
type
label
The Shank family of scaffold proteins
@ast
The Shank family of scaffold proteins
@en
The Shank family of scaffold proteins
@nl
prefLabel
The Shank family of scaffold proteins
@ast
The Shank family of scaffold proteins
@en
The Shank family of scaffold proteins
@nl
P3181
P1476
The Shank family of scaffold proteins
@en
P304
P3181
P407
P478
113 ( Pt 11)
P577
2000-06-01T00:00:00Z