Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
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Telomerase modulates Wnt signalling by association with target gene chromatinThe telomere syndromesHuman heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiationOxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2Repair of cyclobutane pyrimidine dimers or dimethylsulfate damage in DNA is identical in normal or telomerase-immortalized human skin fibroblasts.Aging and radiation: bad companionsSingle-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangsGenomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient miceTelomere shortening exposes functions for the mouse Werner and Bloom syndrome genesDNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouseEssential role of limiting telomeres in the pathogenesis of Werner syndromeA highly selective telomerase inhibitor limiting human cancer cell proliferationNatural and pharmacological regulation of telomeraseTelomerase deficiency affects the formation of chromosomal translocations by homologous recombination in Saccharomyces cerevisiae.A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis.Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast.Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomeraseSyndromes of telomere shorteningOn the capturing of low-energy electrons by DNA.The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors.The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction.Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.The telomere/telomerase binding factor PinX1 is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomas.Telomere profiling: toward glioblastoma personalized medicine.Many ways to telomere dysfunction: in vivo studies using mouse models.Phosphorylation of H2AX at short telomeres in T cells and fibroblasts.Short telomeres induce a DNA damage response in Saccharomyces cerevisiae.Replication proteins influence the maintenance of telomere length and telomerase protein stabilityTelomere attrition and Chk2 activation in human heart failureMolecular parameters of hyperthermia for radiosensitization.Trastuzumab increases the sensitivity of HER2-amplified human gastric cancer cells to oxaliplatin and cisplatin by affecting the expression of telomere-associated proteinsMolecular adaptation of telomere associated genes in mammals.Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells.Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptaseTelomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells.Telomerase as a novel and potentially selective target for cancer chemotherapy.Reversibility of replicative senescence in Saccharomyces cerevisiae: effect of homologous recombination and cell cycle checkpoints.Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy
P2860
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P2860
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
description
2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
@ast
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
@en
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
@nl
type
label
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
@ast
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
@en
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
@nl
prefLabel
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
@ast
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
@en
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
@nl
P2093
P3181
P356
P1433
P1476
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
@en
P2093
G J Gottlieb
J Chaudhuri
K L Rudolph
R A DePinho
S E Artandi
P2888
P3181
P356
10.1038/79232
P407
P577
2000-09-01T00:00:00Z