Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair.
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BRCTx is a novel, highly conserved RAD18-interacting proteinFunctional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppressionYeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends.The response to and repair of RAG-mediated DNA double-strand breaksOverexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/AktThe role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlFertility defects revealing germline biallelic nonsense NBN mutationsAn essential function for NBS1 in the prevention of ataxia and cerebellar defectsRad50 is dispensable for the maintenance and viability of postmitotic tissuesc-Myc directly regulates the transcription of the NBS1 gene involved in DNA double-strand break repairNibrin functions in Ig class-switch recombinationATR: an essential regulator of genome integrityThe MRN-CtIP pathway is required for metaphase chromosome alignment.Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development.Targeted deletion of p73 in mice reveals its role in T cell development and lymphomagenesisHistone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombinationGenomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.Phosphorylation stabilizes Nanog by promoting its interaction with Pin1The MRN complex in double-strand break repair and telomere maintenance.The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.The MRN complex: coordinating and mediating the response to broken chromosomes.Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity.ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaksDisruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.Nbn and atm cooperate in a tissue and developmental stage-specific manner to prevent double strand breaks and apoptosis in developing brain and eye.Oxidative stress in ataxia telangiectasia.Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation.A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons.Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma.Molecular basis of ataxia telangiectasia and related diseases.Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosisDNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis.DNA-damage repair; the good, the bad, and the ugly.The ATM signaling network in development and disease.DNA double-strand break repair and development.Induction of genetic instability by gain-of-function p53 cancer mutants.Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBSRecognition of DNA double strand breaks by the BRCA1 tumor suppressor network.
P2860
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P2860
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair.
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2002 nî lūn-bûn
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2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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name
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
@nl
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair.
@ast
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair.
@en
type
label
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
@nl
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair.
@ast
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair.
@en
prefLabel
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
@nl
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair.
@ast
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair.
@en
P2093
P2860
P356
P1433
P1476
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair.
@en
P2093
Roderick T Bronson
P2860
P304
P356
10.1093/EMBOJ/21.6.1447
P407
P577
2002-03-01T00:00:00Z