Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression
about
Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATMNBS1, the Nijmegen breakage syndrome gene product, regulates neuronal proliferation and differentiationRole of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesisAnalysis of DNA double-strand break response and chromatin structure in mitosis using laser microirradiation.BRIT1 regulates early DNA damage response, chromosomal integrity, and cancerSingle cell cytometry of protein function in RNAi treated cells and in native populationsInduced apoptosis in melanocytes cancer cell and oxidation in biomolecules through deuterium oxide generated from atmospheric pressure non-thermal plasma jet.DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.H2AX: functional roles and potential applications.Mutation inactivation of Nijmegen breakage syndrome gene (NBS1) in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse modelA kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiationDistinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosisDNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis.Candidate protein biodosimeters of human exposure to ionizing radiation.Induction of genetic instability by gain-of-function p53 cancer mutants.Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage.Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells.The human intra-S checkpoint response to UVC-induced DNA damage.FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistanceMolecular nature of radiation injury and DNA repair disorders associated with radiosensitivity.DNA damage sensing by the ATM and ATR kinases.Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.Neurotoxin-induced DNA damage is persistent in SH-SY5Y cells and LC neurons.Systematic identification of functional residues in mammalian histone H2AXThe ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends.hSMG-1 is a granzyme B-associated stress-responsive protein kinase.Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining.Development of a high-throughput human HepG(2) dual luciferase assay for detection of metabolically activated hepatotoxicants and genotoxicants.Inverse dose-rate-effects on the expressions of extra-cellular matrix-related genes in low-dose-rate gamma-ray irradiated murine cells.Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells.The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.Extent of constitutive histone H2AX phosphorylation on Ser-139 varies in cells with different TP53 status.Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppressionA hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis.Chromodomain helicase DNA-binding protein 2 affects the repair of X-ray and UV-induced DNA damage.p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system.
P2860
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P2860
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Functional interaction of H2AX ...... esponses and tumor suppression
@ast
Functional interaction of H2AX ...... esponses and tumor suppression
@en
Functional interaction of H2AX ...... esponses and tumor suppression
@nl
type
label
Functional interaction of H2AX ...... esponses and tumor suppression
@ast
Functional interaction of H2AX ...... esponses and tumor suppression
@en
Functional interaction of H2AX ...... esponses and tumor suppression
@nl
prefLabel
Functional interaction of H2AX ...... esponses and tumor suppression
@ast
Functional interaction of H2AX ...... esponses and tumor suppression
@en
Functional interaction of H2AX ...... esponses and tumor suppression
@nl
P2093
P2860
P1476
Functional interaction of H2AX ...... esponses and tumor suppression
@en
P2093
Craig Bassing
David Ferguson
Frederick W Alt
Hoseok Song
Mark Eckersdorff
P2860
P304
P356
10.1128/MCB.25.2.661-670.2005
P407
P577
2005-01-01T00:00:00Z