Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
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The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxiaMammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulationEvidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygenA yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor proteinThe peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stabilityFIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factorModulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alphaIOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activityPyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alphaInactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activationInteraction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathwaysAsparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factorASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanismStructure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alphaTranscriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylationThe candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alphaBiochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway.Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)Hypoxic regulation of erythropoiesis and iron metabolismThe VHL tumor suppressor: master regulator of HIFThe human side of hypoxia-inducible factorIdentification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alphaStudies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assayHIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxiaThe VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activityHypoxia: not merely a regulator of angiogenesis?Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancersOxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiologyHypoxia and its implications in rheumatoid arthritisRodent Hypoxia-Ischemia Models for Cerebral Palsy Research: A Systematic ReviewDUBs, New Members in the Hypoxia Signaling clUbTargeting Protein-Protein Interactions in the HIF SystemExploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models
P2860
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P2860
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
@ast
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
@en
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
@nl
type
label
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
@ast
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
@en
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
@nl
prefLabel
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
@ast
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
@en
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
@nl
P2093
P3181
P356
P1433
P1476
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
@en
P2093
Dean A Whelan
Jeffrey J Gorman
Murray L Whitelaw
P304
P3181
P356
10.1126/SCIENCE.1068592
P407
P577
2002-02-01T00:00:00Z