The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation - Test2 - elhamkhani - TriplyDB

The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

http://www.wikidata.org/entity/Q28184480

about

Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7 The chromosome cycle: coordinating replication and segregation. Second in the cycles review series.Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis Prevention of DNA re-replication in eukaryotic cells Replication licensing and cancer--a fatal entanglement?Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer Preventing re-replication of chromosomal DNA.Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress Genomic instability in cancer.Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation Helicase loading at chromosomal origins of replication CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination Cellular checkpoint mechanisms monitoring proper initiation of DNA replication USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1.RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.DDB1 maintains genome integrity through regulation of Cdt1 The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis.SKP2A, an F-box protein that regulates cell division, is degraded via the ubiquitin pathway.The Control of Arabidopsis thaliana Growth by Cell Proliferation and Endoreplication Requires the F-Box Protein FBL17.The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development.A general framework for modeling growth and division of mammalian cells Cancer models in Caenorhabditis elegans.SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication.The emerging role of the COP9 signalosome in cancer.CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs.Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.Chinese hamster ORC subunits dynamically associate with chromatin throughout the cell-cycle

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The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

http://www.wikidata.org/entity/Q28184480

description

2003 nî lūn-bûn

@nan

2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

@wuu

name

The SCF(Skp2) ubiquitin ligase ...... and regulates Cdt1 degradation

@ast

The SCF(Skp2) ubiquitin ligase ...... and regulates Cdt1 degradation

@en

The SCF(Skp2) ubiquitin ligase ...... and regulates Cdt1 degradation

@nl

type

label

The SCF(Skp2) ubiquitin ligase ...... and regulates Cdt1 degradation

@ast

The SCF(Skp2) ubiquitin ligase ...... and regulates Cdt1 degradation

@en

The SCF(Skp2) ubiquitin ligase ...... and regulates Cdt1 degradation

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prefLabel

The SCF(Skp2) ubiquitin ligase ...... and regulates Cdt1 degradation

@ast

The SCF(Skp2) ubiquitin ligase ...... and regulates Cdt1 degradation

@en

The SCF(Skp2) ubiquitin ligase ...... and regulates Cdt1 degradation

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P1433

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P1433

Journal of Biological Chemistry

P1476

The SCF(Skp2) ubiquitin ligase ...... and regulates Cdt1 degradation

@en

P2093

Peiqing Sun

http://www.w3.org/2001/XMLSchema#string

Qiping Zhao

http://www.w3.org/2001/XMLSchema#string

Rong Liao

http://www.w3.org/2001/XMLSchema#string

Xianghong Li

http://www.w3.org/2001/XMLSchema#string

Xiaohua Wu

http://www.w3.org/2001/XMLSchema#string

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Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase

A human protein related to yeast Cdc6p

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6

A system for stable expression of short interfering RNAs in mammalian cells

Ubiquitin-dependent protein degradation

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30854-8

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scholarly article

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1644448

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P356

10.1074/JBC.C300251200

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P407

P433

33

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P478

278

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2003-08-15T00:00:00Z

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P698

12840033

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