Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins
about
The ubiquilin gene family: evolutionary patterns and functional insightsAlzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formationUbiquilin functions in autophagy and is degraded by chaperone-mediated autophagyUbiquilin and p97/VCP bind erasin, forming a complex involved in ERADUbiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrinUbiquilin-1 is a molecular chaperone for the amyloid precursor proteinUbiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradationDimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilinsThe Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord InjuryAffinity Makes the Difference: Nonselective Interaction of the UBA Domain of Ubiquilin-1 with Monomeric Ubiquitin and Polyubiquitin ChainsALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1Aggresome formation and neurodegenerative diseases: therapeutic implicationsUbiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells.Ubiquitin domain proteins in disease.Glial fibrillary acidic protein is elevated in the lysosomal storage disease classical late-infantile neuronal ceroid lipofuscinosis, but is not a component of the storage material.Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's diseaseProtein aggregation and degradation mechanisms in neurodegenerative diseasesSignature changes in ubiquilin expression in the R6/2 mouse model of Huntington's disease.Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS Mutations.The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidUbiquitin receptors and protein quality controlStudies of the role of ubiquitination in the interaction of ubiquilin with the loop and carboxyl terminal regions of presenilin-2The Ubiquitination, Disaggregation and Proteasomal Degradation Machineries in Polyglutamine DiseaseAggrephagy: selective disposal of protein aggregates by macroautophagy.Targeting ubiquilin-1 in Alzheimer's disease.The role of ubiquitin-binding domains in human pathophysiology.Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation.The Role of Presenilin-1 in the Excitotoxicity of Ethanol Withdrawal.The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.Ubiquilin-1 and protein quality control in Alzheimer diseaseTranscriptional profile of GTP-mediated differentiation of C2C12 skeletal muscle cells.Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.An AICD-based functional screen to identify APP metabolism regulators.Ubiquilin overexpression reduces GFP-polyalanine-induced protein aggregates and toxicity.Ubiquilin-1 regulates nicotine-induced up-regulation of neuronal nicotinic acetylcholine receptors.Meta-analysis of Ubiquilin1 gene polymorphism and Alzheimer's disease risk.Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila.Association of UBQ-8i polymorphism with Alzheimer's disease in Caucasians: a meta-analysis.Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS.
P2860
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P2860
Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins
description
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Februar 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: February 2004)
@en
vedecký článok (publikovaný 2004-02)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd in 2004-02)
@nl
наукова стаття, опублікована в лютому 2004
@uk
مقالة علمية (نشرت في فبراير 2004)
@ar
name
Overexpression of ubiquilin de ...... adation of presenilin proteins
@ast
Overexpression of ubiquilin de ...... adation of presenilin proteins
@en
Overexpression of ubiquilin de ...... adation of presenilin proteins
@nl
type
label
Overexpression of ubiquilin de ...... adation of presenilin proteins
@ast
Overexpression of ubiquilin de ...... adation of presenilin proteins
@en
Overexpression of ubiquilin de ...... adation of presenilin proteins
@nl
prefLabel
Overexpression of ubiquilin de ...... adation of presenilin proteins
@ast
Overexpression of ubiquilin de ...... adation of presenilin proteins
@en
Overexpression of ubiquilin de ...... adation of presenilin proteins
@nl
P2093
P356
P1476
Overexpression of ubiquilin de ...... adation of presenilin proteins
@en
P2093
Alex L Mah
Diana L Ford
Howard Doong
Jaime Miller
Jing Liang
Leann K Massey
Mervyn J Monteiro
P356
10.3233/JAD-2004-6109
P407
P577
2004-02-01T00:00:00Z