Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins - Test2 - elhamkhani - TriplyDB

Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins

Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins

http://www.wikidata.org/entity/Q28248771

about

The ubiquilin gene family: evolutionary patterns and functional insights Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord Injury Affinity Makes the Difference: Nonselective Interaction of the UBA Domain of Ubiquilin-1 with Monomeric Ubiquitin and Polyubiquitin Chains ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1 Aggresome formation and neurodegenerative diseases: therapeutic implications Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells.Ubiquitin domain proteins in disease.Glial fibrillary acidic protein is elevated in the lysosomal storage disease classical late-infantile neuronal ceroid lipofuscinosis, but is not a component of the storage material.Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease Protein aggregation and degradation mechanisms in neurodegenerative diseases Signature changes in ubiquilin expression in the R6/2 mouse model of Huntington's disease.Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS Mutations.The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid Ubiquitin receptors and protein quality control Studies of the role of ubiquitination in the interaction of ubiquilin with the loop and carboxyl terminal regions of presenilin-2 The Ubiquitination, Disaggregation and Proteasomal Degradation Machineries in Polyglutamine Disease Aggrephagy: selective disposal of protein aggregates by macroautophagy.Targeting ubiquilin-1 in Alzheimer's disease.The role of ubiquitin-binding domains in human pathophysiology.Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation.The Role of Presenilin-1 in the Excitotoxicity of Ethanol Withdrawal.The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.Ubiquilin-1 and protein quality control in Alzheimer disease Transcriptional profile of GTP-mediated differentiation of C2C12 skeletal muscle cells.Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.An AICD-based functional screen to identify APP metabolism regulators.Ubiquilin overexpression reduces GFP-polyalanine-induced protein aggregates and toxicity.Ubiquilin-1 regulates nicotine-induced up-regulation of neuronal nicotinic acetylcholine receptors.Meta-analysis of Ubiquilin1 gene polymorphism and Alzheimer's disease risk.Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila.Association of UBQ-8i polymorphism with Alzheimer's disease in Caucasians: a meta-analysis.Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS.

P2860

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P2860

Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins

http://www.wikidata.org/entity/Q28248771

description

2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2004

@ast

im Februar 2004 veröffentlichter wissenschaftlicher Artikel

@de

scientific article (publication date: February 2004)

@en

vedecký článok (publikovaný 2004-02)

@sk

vědecký článek publikovaný v roce 2004

@cs

wetenschappelijk artikel (gepubliceerd in 2004-02)

@nl

наукова стаття, опублікована в лютому 2004

@uk

مقالة علمية (نشرت في فبراير 2004)

@ar

name

Overexpression of ubiquilin de ...... adation of presenilin proteins

@ast

Overexpression of ubiquilin de ...... adation of presenilin proteins

@en

Overexpression of ubiquilin de ...... adation of presenilin proteins

@nl

type

label

Overexpression of ubiquilin de ...... adation of presenilin proteins

@ast

Overexpression of ubiquilin de ...... adation of presenilin proteins

@en

Overexpression of ubiquilin de ...... adation of presenilin proteins

@nl

prefLabel

Overexpression of ubiquilin de ...... adation of presenilin proteins

@ast

Overexpression of ubiquilin de ...... adation of presenilin proteins

@en

Overexpression of ubiquilin de ...... adation of presenilin proteins

@nl

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P356

P1433

Journal of Alzheimer's Disease

P1476

Overexpression of ubiquilin de ...... adation of presenilin proteins

@en

P2093

Alex L Mah

http://www.w3.org/2001/XMLSchema#string

Diana L Ford

http://www.w3.org/2001/XMLSchema#string

Howard Doong

http://www.w3.org/2001/XMLSchema#string

Jaime Miller

http://www.w3.org/2001/XMLSchema#string

Jing Liang

http://www.w3.org/2001/XMLSchema#string

Leann K Massey

http://www.w3.org/2001/XMLSchema#string

Mervyn J Monteiro

http://www.w3.org/2001/XMLSchema#string

P304

79-92

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P31

scholarly article

P356

10.3233/JAD-2004-6109

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

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P478

6

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P577

2004-02-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15004330

http://www.w3.org/2001/XMLSchema#string

P921

protein ubiquitination