Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability - Test2 - elhamkhani - TriplyDB

Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability

Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability

http://www.wikidata.org/entity/Q28253489

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Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response Epigenetic Codes Programing Class Switch Recombination Parasite Infection, Carcinogenesis and Human Malignancy Emerging concepts of epigenetic dysregulation in hematological malignancies AID/APOBEC deaminases and cancer RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome AID targeting: old mysteries and new challenges Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb dbSUPER: a database of super-enhancers in mouse and human genome Enhancers and chromatin structures: regulatory hubs in gene expression and diseases.Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?Enhancers as non-coding RNA transcription units: recent insights and future perspectives.B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.Epigenetic targeting of activation-induced cytidine deaminase.Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity.Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells.Exceptional Antibodies Produced by Successive Immunizations.Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells.Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells.Defining chromosomal translocation risks in cancer.Highly sensitive and unbiased approach for elucidating antibody repertoires.AID hits the jackpot when missing the target.7SK-BAF axis controls pervasive transcription at enhancers.Activation-Induced Cytidine Deaminase Links Ovulation-Induced Inflammation and Serous Carcinogenesis UNG protects B cells from AID-induced telomere loss.The cell cycle restricts activation-induced cytidine deaminase activity to early G1.Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome.The IgH locus 3' cis-regulatory super-enhancer co-opts AID for allelic transvection.Regulating infidelity: RNA-mediated recruitment of AID to DNA during class switch recombination A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket.Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes Enhancer-associated RNAs as therapeutic targets.Short-Circuiting Gene Regulatory Networks: Origins of B Cell Lymphoma AID Recognizes Structured DNA for Class Switch Recombination.Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells

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Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability

http://www.wikidata.org/entity/Q28253489

description

2014 nî lūn-bûn

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2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Convergent transcription at in ...... -initiated genomic instability

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Convergent transcription at in ...... -initiated genomic instability

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Convergent transcription at in ...... -initiated genomic instability

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type

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Convergent transcription at in ...... -initiated genomic instability

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Convergent transcription at in ...... -initiated genomic instability

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Convergent transcription at in ...... -initiated genomic instability

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prefLabel

Convergent transcription at in ...... -initiated genomic instability

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Convergent transcription at in ...... -initiated genomic instability

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Convergent transcription at in ...... -initiated genomic instability

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J.CELL.2014.11.014

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Caitlyn R Wasserman

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Corina Amor

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Donna Neuberg

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Frederick W Alt

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James E Bradner

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Kyong-Rim Kieffer-Kwon

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Michel C Nussenzweig

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Qiao Wang

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Rafael Casellas

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X Shirley Liu

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Model-based analysis of ChIP-Seq (MACS)

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

Histone H3K27ac separates active from poised enhancers and predicts developmental state

Enhancer RNAs and regulated transcriptional programs

Fast gapped-read alignment with Bowtie 2

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters

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1538-1548

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scholarly article

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10.1016/J.CELL.2014.11.014

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Alexander J Federation

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