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CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

http://www.wikidata.org/entity/Q28259261

about

Replication licensing and cancer--a fatal entanglement?Primase directs the release of DnaC from DnaB Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis.Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability Sparstolonin B inhibits pro-angiogenic functions and blocks cell cycle progression in endothelial cells Cell Division Cycle 6 Promotes Mitotic Slippage and Contributes to Drug Resistance in Paclitaxel-Treated Cancer Cells Cohesin organizes chromatin loops at DNA replication factories.MiR-886-3p regulates cell proliferation and migration, and is dysregulated in familial non-medullary thyroid cancer.Microarray analysis of RNA extracted from formalin-fixed, paraffin-embedded and matched fresh-frozen ovarian adenocarcinomas.Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.Cdk2 is required for p53-independent G2/M checkpoint control.Activation of Cdc6 by MyoD is associated with the expansion of quiescent myogenic satellite cells.Cdc6 contributes to abrogating the G1 checkpoint under hypoxic conditions in HPV E7 expressing cells.Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFβ-dependent mechanism.Alterations in RD(INK4/ARF) -mediated en bloc regulation of the INK4-ARF locus in human squamous cell carcinoma of the head and neck.A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition EMT in zebrafish.Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function.Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination.Susceptibility to DNA damage as a molecular mechanism for non-syndromic cleft lip and palate.Methylation of tumor suppressor genes is related with copy number aberrations in breast cancer Redox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcription Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins.Expression Analysis of Genes Involved in the RB/E2F Pathway in Astrocytic Tumors.Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCFCdc4 recognition in Saccharomyces cerevisiae.Juvenile Hormone Activates the Transcription of Cell-division-cycle 6 (Cdc6) for Polyploidy-dependent Insect Vitellogenesis and Oogenesis CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle.Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation Oligonucleotide microarray analysis of apoptosis induced by 15-methoxypinusolidic acid in microglial BV2 cells.Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells.Cyclin E is stabilized in response to replication fork barriers leading to prolonged S phase arrest.WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck.DnaA, ORC, and Cdc6: similarity beyond the domains of life and diversity.Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling.AAV-Mediated angiotensin 1-7 overexpression inhibits tumor growth of lung cancer in vitro and in vivo DNA replication licensing control and rereplication prevention.Cdc6: a multi-functional molecular switch with critical role in carcinogenesis Hyperosmotic stress induces cell cycle arrest in retinal pigmented epithelial cells.

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P2860

CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

http://www.wikidata.org/entity/Q28259261

description

2008 nî lūn-bûn

@nan

2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年論文

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2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

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2008年论文

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name

CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

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CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

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CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

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type

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CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

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CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

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CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

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prefLabel

CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

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CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

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CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

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CDC6: from DNA replication to cell cycle checkpoints and oncogenesis

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P2093

Luis R Borlado

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P2860

Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase

A human protein related to yeast Cdc6p

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization

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237-243

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scholarly article

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2836417

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10.1093/CARCIN/BGM268

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2

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29

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2007-11-28T00:00:00Z

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5800341

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18048387

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