Cdc6 protein causes premature entry into S phase in a mammalian cell-free system. - Test2 - elhamkhani - TriplyDB

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

http://www.wikidata.org/entity/Q24533451

about

PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells Distinctive activities of DNA polymerases during human DNA replication The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1 Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6 Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa Functional requirement of noncoding Y RNAs for human chromosomal DNA replication HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication The Croonian Lecture 2001 hunting the antisocial cancer cell: MCM proteins and their exploitation Visualization of bidirectional initiation of chromosomal DNA replication in a human cell free system Expression of minichromosome maintenance protein 2 as a marker for proliferation and prognosis in diffuse large B-cell lymphoma: a tissue microarray and clinico-pathological analysis.In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication BRCT domain-containing protein TopBP1 functions in DNA replication and damage response Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase CDC6: from DNA replication to cell cycle checkpoints and oncogenesis Origin recognition and the chromosome cycle Mammalian MCM loading in late-G(1) coincides with Rb hyperphosphorylation and the transition to post-transcriptional control of progression into S-phase Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A.RPA is an initiation factor for human chromosomal DNA replication.Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer.Xenopus Cdc6 performs separate functions in initiating DNA replication Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation.S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human cells.Initiation of eukaryotic DNA replication: conservative or liberal?Analysis of Cdc6 function in the assembly of mammalian prereplication complexes Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle.Ras-dependent cell cycle commitment during G2 phase.Replication licensing--defining the proliferative state?Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.Human Cdc45 is a proliferation-associated antigen.Reduced expression of GINS complex members induces hallmarks of pre-malignancy in primary untransformed human cells Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro.Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle Meier-Gorlin syndrome mutations disrupt an Orc1 CDK inhibitory domain and cause centrosome reduplication Targeting of cytosolic phospholipase A2α impedes cell cycle re-entry of quiescent prostate cancer cells.

P2860

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P2860

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

http://www.wikidata.org/entity/Q24533451

description

1998 nî lūn-bûn

@nan

1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system

@nl

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

@ast

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

@en

type

label

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system

@nl

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

@ast

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

@en

prefLabel

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system

@nl

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

@ast

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

@en

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P1433

The EMBO Journal

P1476

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

@en

P2093

A D Mills

http://www.w3.org/2001/XMLSchema#string

G H Williams

http://www.w3.org/2001/XMLSchema#string

K Marheineke

http://www.w3.org/2001/XMLSchema#string

K Stoeber

http://www.w3.org/2001/XMLSchema#string

P Romanowski

http://www.w3.org/2001/XMLSchema#string

R A Laskey

http://www.w3.org/2001/XMLSchema#string

Y Kubota

http://www.w3.org/2001/XMLSchema#string

P2860

Conserved initiator proteins in eukaryotes

A human protein related to yeast Cdc6p

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division

Different roles for cyclins D1 and E in regulation of the G1-to-S transition

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast.

Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs.

P304

7219-7229

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scholarly article

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10.1093/EMBOJ/17.24.7219

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P407

P433

24

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P478

17

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P50

P577

1998-12-01T00:00:00Z

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P5875

13430968

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P698

9857179

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P932

1171068

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