Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
about
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascadesIRF7: activation, regulation, modification and functionReconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunityMAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune responseMapping a dynamic innate immunity protein interaction network regulating type I interferon productionFunction and regulation of retinoic acid-inducible gene-ICytosolic Innate Immune Sensing and Signaling upon InfectionUbiquitin signaling in immune responsesUbiquitin in the activation and attenuation of innate antiviral immunityInterferon induction by RNA viruses and antagonism by viral pathogensThe role of ubiquitylation in immune defence and pathogen evasionRegulation of inflammatory and antiviral signaling by A20.Molecular Biology and Infection of Hepatitis E VirusPhosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activationProtein-protein interaction antagonists as novel inhibitors of non-canonical polyubiquitylationHuman genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon responseMechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway.TRAF5 is a downstream target of MAVS in antiviral innate immune signaling.Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.Novel roles of cytoplasmic ICP0: proteasome-independent functions of the RING finger are required to block interferon-stimulated gene production but not to promote viral replication.Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defenseSTING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathwayMAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptorsTRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response.NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses.COX5B regulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS productionLysine 63-linked TANK-binding kinase 1 ubiquitination by mindbomb E3 ubiquitin protein ligase 2 is mediated by the mitochondrial antiviral signaling protein.Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses.A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responsesHSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1.Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradationNew mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein.Targeting signaling factors for degradation, an emerging mechanism for TRAF functionsHepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate ImmunityYmer acts as a multifunctional regulator in nuclear factor-κB and Fas signaling pathways.RIG-I Mediates an Antiviral Response to Crimean-Congo Hemorrhagic Fever VirusSerine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signalingGPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosomeUbiquitination in the antiviral immune responseβ-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H.
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P2860
Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
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2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
@ast
Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
@en
Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
@nl
type
label
Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
@ast
Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
@en
Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
@nl
prefLabel
Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
@ast
Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
@en
Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
@nl
P2093
P2860
P3181
P1433
P1476
Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
@en
P2093
P2860
P304
P3181
P356
10.1016/J.MOLCEL.2009.09.037
P407
P577
2009-10-01T00:00:00Z