Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits.
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mTOR is a key modulator of ageing and age-related diseaseThe Function of Autophagy in Neurodegenerative DiseasesDual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptideAutophagy and neurodegenerationMechanisms of age-related macular degenerationThe role of tau in neurodegenerative diseases and its potential as a therapeutic targetShedding new light on neurodegenerative diseases through the mammalian target of rapamycinAdministration of a selective β2 adrenergic receptor antagonist exacerbates neuropathology and cognitive deficits in a mouse model of Alzheimer's diseaseAge-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's DiseasePotential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disordersACAT1/SOAT1 as a therapeutic target for Alzheimer's diseaseEssential role for autophagy in life span extensionPim1 inhibition as a novel therapeutic strategy for Alzheimer's diseaseRapalogs and mTOR inhibitors as anti-aging therapeuticsRapamycin attenuates the progression of tau pathology in P301S tau transgenic micemTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease.Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession.mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signaturep62 improves AD-like pathology by increasing autophagyGenetic suppression of β2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies.The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease.Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic miceThe β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits.Activation of mTOR ameliorates fragile X premutation rCGG repeat-mediated neurodegenerationInduction of autophagy by a novel small molecule improves aβ pathology and ameliorates cognitive deficitsRegulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy.Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathologySynthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance.Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.VGF expression by T lymphocytes in patients with Alzheimer's diseaseRedox regulation of autophagy in healthy brain and neurodegeneration.Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy.Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.Oxygen-glucose deprivation regulates BACE1 expression through induction of autophagy in Neuro-2a/APP695 cells
P2860
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P2860
Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Inducing autophagy by rapamyci ...... meliorates cognitive deficits.
@ast
Inducing autophagy by rapamyci ...... meliorates cognitive deficits.
@en
Inducing autophagy by rapamyci ...... meliorates cognitive deficits.
@nl
type
label
Inducing autophagy by rapamyci ...... meliorates cognitive deficits.
@ast
Inducing autophagy by rapamyci ...... meliorates cognitive deficits.
@en
Inducing autophagy by rapamyci ...... meliorates cognitive deficits.
@nl
prefLabel
Inducing autophagy by rapamyci ...... meliorates cognitive deficits.
@ast
Inducing autophagy by rapamyci ...... meliorates cognitive deficits.
@en
Inducing autophagy by rapamyci ...... meliorates cognitive deficits.
@nl
P2093
P2860
P1433
P1476
Inducing autophagy by rapamyci ...... meliorates cognitive deficits.
@en
P2093
Arlan Richardson
Randy Strong
Salvatore Oddo
Smita Majumder
P2860
P304
P356
10.1371/JOURNAL.PONE.0025416
P407
P577
2011-09-28T00:00:00Z