VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
about
The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnoverVprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelityMerlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleusPCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infectionVpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tailThe role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implicationsNeurofibromatosis type 2 protein, NF2: an uncoventional cell cycle regulator.CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growthUbiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancerMissense mutations in the NF2 gene result in the quantitative loss of merlin protein and minimally affect protein intrinsic function.The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2).VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligasesDefining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest.Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype.Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair responseSCF E3 ubiquitin ligases as anticancer targets.Pathogenic Role of the CRL4 Ubiquitin Ligase in Human DiseaseCRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.DCAF1 controls T-cell function via p53-dependent and -independent mechanismsDyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradationHIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complexRBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival.DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress.CRL4s: the CUL4-RING E3 ubiquitin ligases.Roles of Vpr and Vpx in modulating the virus-host cell relationship.Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase.Purification of the COP9 signalosome complex and binding partners from human T cells.Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP.HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrestTargeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complexMultistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin.Targeting protein ubiquitylation: DDB1 takes its RING offChromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy.
P2860
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P2860
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
@ast
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
@en
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
@nl
type
label
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
@ast
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
@en
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
@nl
prefLabel
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
@ast
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
@en
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
@nl
P356
P1433
P1476
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
@en
P2888
P304
P356
10.1038/ONC.2008.44
P407
P577
2008-07-03T00:00:00Z
P5875
P6179
1005220717