CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10. - Test2 - elhamkhani - TriplyDB

CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

http://www.wikidata.org/entity/Q36180198

about

Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1 The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage.Methylation of histone H4 at aspartate 24 by protein L-isoaspartate O-methyltransferase (PCMT1) links histone modifications with protein homeostasis.VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest.HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.DCAF1 controls T-cell function via p53-dependent and -independent mechanisms Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase.Enigmatic roles of Mcm10 in DNA replication Molecular insights into NF2/Merlin tumor suppressor function.HIV-1 Vpr Protein Induces Proteasomal Degradation of Chromatin-associated Class I HDACs to Overcome Latent Infection of Macrophages.VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1.Monocyte Chemoattractant Protein-Induced Protein 1 Overexpression Modulates Transcriptome, Including MicroRNA, in Human Neuroblastoma Cells.Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches.Mcm10: A Dynamic Scaffold at Eukaryotic Replication Forks Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP.Cep78 controls centrosome homeostasis by inhibiting EDD-DYRK2-DDB1VprBP.DCAF1 is involved in HCV replication through regulation of miR-122.Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy.Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System.

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P2860

CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

http://www.wikidata.org/entity/Q36180198

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

@ast

CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

@en

type

label

CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

@ast

CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

@en

prefLabel

CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

@ast

CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

@en

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Nucleic Acids Research

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CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10

@en

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Aparna Sharma

http://www.w3.org/2001/XMLSchema#string

Manpreet Kaur

http://www.w3.org/2001/XMLSchema#string

Md Muntaz Khan

http://www.w3.org/2001/XMLSchema#string

Sandeep Saxena

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P2860

Hexameric ring structure of human MCM10 DNA replication factor

HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase

Domain architecture and biochemical characterization of vertebrate Mcm10

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7332-7346

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scholarly article

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10.1093/NAR/GKS366

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15

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22570418

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3424545

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