The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together
about
The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldariusBLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repairA divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatinATMIN defines an NBS1-independent pathway of ATM signallingDNA resection in eukaryotes: deciding how to fix the breakMRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patensTelomere shortening in human diseasesStructure of a Second BRCT Domain Identified in the Nijmegen Breakage Syndrome Protein Nbs1 and its Function in an MDC1-Dependent Localization of Nbs1 to DNA Damage SitesThe Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break RepairRad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.Interactions between Mei4, Rec114, and other proteins required for meiotic DNA double-strand break formation in Saccharomyces cerevisiaeNuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cellsRAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing geneThe response to and repair of RAG-mediated DNA double-strand breaksClinical significance of increased expression of Nijmegen breakage syndrome gene (NBS1) in human primary liver cancerATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaksZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing overAn essential function for NBS1 in the prevention of ataxia and cerebellar defectsChk2 suppresses the oncogenic potential of DNA replication-associated DNA damageNever-in-mitosis related kinase 1 functions in DNA damage response and checkpoint controlDouble strand break repair functions of histone H2AXRole of mammalian Mre11 in classical and alternative nonhomologous end joiningC. elegans germ cells switch between distinct modes of double-strand break repair during meiotic prophase progressionIdentification of Plasmodium falciparum DNA Repair Protein Mre11 with an Evolutionarily Conserved Nuclease FunctionThe MRN-CtIP pathway is required for metaphase chromosome alignment.DNA double strand break repair enzymes function at multiple steps in retroviral infection.Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.Autophosphorylation and ATM activation: additional sites add to the complexity.Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones.The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes.In my end is my beginning: control of end resection and DSBR pathway 'choice' by cyclin-dependent kinases.Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates.The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevisDNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2.Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replication
P2860
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P2860
The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together
description
2004 nî lūn-bûn
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2004 թուականին հրատարակուած գիտական յօդուած
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2004 թվականին հրատարակված գիտական հոդված
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年學術文章
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name
The Mre11 complex and the meta ...... ng and holding things together
@ast
The Mre11 complex and the meta ...... ng and holding things together
@en
The Mre11 complex and the meta ...... ng and holding things together
@nl
type
label
The Mre11 complex and the meta ...... ng and holding things together
@ast
The Mre11 complex and the meta ...... ng and holding things together
@en
The Mre11 complex and the meta ...... ng and holding things together
@nl
prefLabel
The Mre11 complex and the meta ...... ng and holding things together
@ast
The Mre11 complex and the meta ...... ng and holding things together
@en
The Mre11 complex and the meta ...... ng and holding things together
@nl
P2093
P1433
P1476
The Mre11 complex and the meta ...... ng and holding things together
@en
P2093
Jan-Willem F Theunissen
John H J Petrini
Monica Morales
P304
P356
10.1016/J.DNAREP.2004.03.014
P407
P577
2004-01-01T00:00:00Z