A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth - Test2 - elhamkhani - TriplyDB

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

http://www.wikidata.org/entity/Q28283339

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Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology Cancer as a metabolic disease The metabolic advantage of tumor cells Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism Altered expression levels of IDH2 are involved in the development of colon cancer Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1α stabilization Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study Targeting cellular metabolism to improve cancer therapeutics Redox-directed cancer therapeutics: molecular mechanisms and opportunities Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy A new view of carcinogenesis and an alternative approach to cancer therapy Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1 Mitochondria, cholesterol and cancer cell metabolism The sweet trap in tumors: aerobic glycolysis and potential targets for therapy Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics Redox biology in pulmonary arterial hypertension (2013 Grover Conference Series)Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?Mitochondrial Dysfunction and Disturbed Coherence: Gate to Cancer.Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect What is good for the circulation also lessens cancer risk Interdisciplinary networks for the treatment of childhood pulmonary vascular disease: what pulmonary hypertension doctors can learn from pediatric oncologists Restoration of mitochondria function as a target for cancer therapy Metabolic reprogramming and metabolic dependency in T cells Application of metabolomics in drug resistant breast cancer research The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer Novel therapeutic targets of tumor metabolism Ion channels and apoptosis in cancer Voltage-gated ion channels in cancer cell proliferation Redox activation of metal-based prodrugs as a strategy for drug delivery

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P2860

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

http://www.wikidata.org/entity/Q28283339

description

2007 nî lūn-bûn

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2007 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2007 թվականի հունվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

A mitochondria-K+ channel axis ...... sis and inhibits cancer growth

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A mitochondria-K+ channel axis ...... sis and inhibits cancer growth

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A mitochondria-K+ channel axis ...... sis and inhibits cancer growth

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type

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A mitochondria-K+ channel axis ...... sis and inhibits cancer growth

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A mitochondria-K+ channel axis ...... sis and inhibits cancer growth

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A mitochondria-K+ channel axis ...... sis and inhibits cancer growth

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prefLabel

A mitochondria-K+ channel axis ...... sis and inhibits cancer growth

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A mitochondria-K+ channel axis ...... sis and inhibits cancer growth

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A mitochondria-K+ channel axis ...... sis and inhibits cancer growth

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A mitochondria-K+ channel axis ...... sis and inhibits cancer growth

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Alois Haromy

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Bernard Thebaud

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Christian Beaulieu

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Christopher T Lee

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Evangelos D Michelakis

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Gwyneth Harry

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Joan Allalunis-Turner

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Kyoko Hashimoto

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Lakshmi Puttagunta

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37-51

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Christopher J Porter

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apoptotic process