Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
about
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repairTumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activationLZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1)Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrolOncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathwayWhat goes on must come off: phosphatases gate-crash the DNA damage responseWip1 phosphatase: between p53 and MAPK kinases pathwaysMosaic PPM1D mutations are associated with predisposition to breast and ovarian cancerCheckpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth.Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL KinaseFourier analysis and systems identification of the p53 feedback loopDistinct phosphatases antagonize the p53 response in different phases of the cell cycleIdentifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression dataDynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention.A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stressThe oncogenic phosphatase WIP1 negatively regulates nucleotide excision repairExpression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation.Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during agingDownregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.The ups and downs of p53: understanding protein dynamics in single cellsWip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage responseSenescence evasion by MCF-7 human breast tumor-initiating cells.PPM1D silencing by RNA interference inhibits the proliferation of lung cancer cellsPhosphatases in the cellular response to DNA damage.Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activityOverexpression of wip1 is associated with biologic behavior in human clear cell renal cell carcinoma.CHK2 kinase in the DNA damage response and beyondPhosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuitDNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase.Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agentsGenetic characterization of breast cancer and implications for clinical managementHDM2 promotes WIP1-mediated medulloblastoma growth.Squalene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 PhosphatasePPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38.PPM1D regulates p21 expression via dephoshporylation at serine 123Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesisMolecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum
P2860
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P2860
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
description
2006 nî lūn-bûn
@nan
2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
@ast
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
@en
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
@nl
type
label
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
@ast
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
@en
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
@nl
prefLabel
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
@ast
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
@en
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
@nl
P2093
P2860
P3181
P356
P1476
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
@en
P2093
H Fujimoto
M Takekawa
P2860
P2888
P304
P3181
P356
10.1038/SJ.CDD.4401801
P407
P50
P577
2005-11-25T00:00:00Z