Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase - Test2 - elhamkhani - TriplyDB

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

http://www.wikidata.org/entity/Q28283888

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Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1)Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway What goes on must come off: phosphatases gate-crash the DNA damage response Wip1 phosphatase: between p53 and MAPK kinases pathways Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer Checkpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth.Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase Fourier analysis and systems identification of the p53 feedback loop Distinct phosphatases antagonize the p53 response in different phases of the cell cycle Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention.A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation.Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.The ups and downs of p53: understanding protein dynamics in single cells Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response Senescence evasion by MCF-7 human breast tumor-initiating cells.PPM1D silencing by RNA interference inhibits the proliferation of lung cancer cells Phosphatases in the cellular response to DNA damage.Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activity Overexpression of wip1 is associated with biologic behavior in human clear cell renal cell carcinoma.CHK2 kinase in the DNA damage response and beyond Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase.Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents Genetic characterization of breast cancer and implications for clinical management HDM2 promotes WIP1-mediated medulloblastoma growth.Squalene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 Phosphatase PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38.PPM1D regulates p21 expression via dephoshporylation at serine 123 Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum

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P2860

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

http://www.wikidata.org/entity/Q28283888

description

2006 nî lūn-bûn

@nan

2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2006 թվականի հուլիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

@ast

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

@en

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

@nl

type

label

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

@ast

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

@en

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

@nl

prefLabel

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

@ast

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

@en

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

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Cell Death & Differentiation

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Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

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P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

Chk2 activates E2F-1 in response to DNA damage

PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways.

Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

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