Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial - Test2 - elhamkhani - TriplyDB

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

http://www.wikidata.org/entity/Q28297270

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Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology Treatment for mitochondrial disorders Treatment for mitochondrial disorders Role of dichloroacetate in the treatment of genetic mitochondrial diseases Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer Targeting Cancer Metabolism - Revisiting the Warburg Effects Mitochondrial disorders in children: toward development of small-molecule treatment strategies Mitochondrial disorders: challenges in diagnosis & treatment Metabolic dysfunction in pulmonary hypertension: the expanding relevance of the Warburg effect Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate Metabolic modulation of glioblastoma with dichloroacetate Dichloroacetate causes reversible demyelination in vitro: potential mechanism for its neuropathic effect Energy failure: does it contribute to neurodegeneration?Gene expression in a Drosophila model of mitochondrial disease.Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenza Metabolic engineering of lactate dehydrogenase rescues mice from acidosis Intramyocellular lipid excess in the mitochondrial disorder MELAS: MRS determination at 7T.Dichloroacetate affects proliferation but not apoptosis in canine mammary cell lines.Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells.Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.Therapeutic prospects for mitochondrial disease.Phenylbutyrate increases pyruvate dehydrogenase complex activity in cells harboring a variety of defects.The neuro-ophthalmology of mitochondrial disease The effect of citrulline and arginine supplementation on lactic acidemia in MELAS syndrome.The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children A modern approach to the treatment of mitochondrial disease Why are there no proven therapies for genetic mitochondrial diseases?DCA promotes progression of neuroblastoma tumors in nude mice.Mitochondrial energetics and therapeutics.Cell-permeable protein therapy for complex I dysfunction Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma.Mitaplatin increases sensitivity of tumor cells to cisplatin by inducing mitochondrial dysfunction.Potential compounds for the treatment of mitochondrial disease.Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases.Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate The proline regulatory axis and cancer Interrelationships of undernutrition and neurotoxicity: food for thought and research attention.

P2860

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P2860

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

http://www.wikidata.org/entity/Q28297270

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2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2006年の論文

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Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

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Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

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