Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells - Test2 - elhamkhani - TriplyDB

Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells

Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells

http://www.wikidata.org/entity/Q28297767

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SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1 ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins Smurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptor Transcription alterations of members of the ubiquitin-proteasome network in prostate carcinoma.Roles of E3 ubiquitin ligases in cell adhesion and migration.The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation.Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein.Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis.Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma.The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial-mesenchymal transition in a sumoylation-regulated manner.Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis Regulation of endothelial barrier function by TGF-β type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90.SMURF1 plays a role in EGF-induced breast cancer cell migration and invasion.Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.Smurf control in bone cells.SMURF and NEDD4: sharp shooters monitor the gate keepers and ion traffic controllers of lead astray cell.Ubiquitination: Added complexity in Ras and Rho family GTPase function.A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.Crosstalk between kinases and Nedd4 family ubiquitin ligases.Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.Regulation of early xenopus embryogenesis by Smad ubiquitination regulatory factor 2.E3 ubiquitin ligases in cancer and implications for therapies.Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System Smurfs in Protein Homeostasis, Signaling, and Cancer

P2860

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P2860

Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells

http://www.wikidata.org/entity/Q28297767

description

2008 nî lūn-bûn

@nan

2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

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2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Smurf2 induces ubiquitin-depen ...... gration of breast cancer cells

@ast

Smurf2 induces ubiquitin-depen ...... gration of breast cancer cells

@en

Smurf2 induces ubiquitin-depen ...... gration of breast cancer cells

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type

label

Smurf2 induces ubiquitin-depen ...... gration of breast cancer cells

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Smurf2 induces ubiquitin-depen ...... gration of breast cancer cells

@en

Smurf2 induces ubiquitin-depen ...... gration of breast cancer cells

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prefLabel

Smurf2 induces ubiquitin-depen ...... gration of breast cancer cells

@ast

Smurf2 induces ubiquitin-depen ...... gration of breast cancer cells

@en

Smurf2 induces ubiquitin-depen ...... gration of breast cancer cells

@nl

P1433

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P2860

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P1433

Journal of Biological Chemistry

P1476

Smurf2 induces ubiquitin-depen ...... gration of breast cancer cells

@en

P2093

Aki Hanyu

http://www.w3.org/2001/XMLSchema#string

Daizo Koinuma

http://www.w3.org/2001/XMLSchema#string

Erina Fukunaga

http://www.w3.org/2001/XMLSchema#string

Kana Horiguchi

http://www.w3.org/2001/XMLSchema#string

Kouichiro Goto

http://www.w3.org/2001/XMLSchema#string

Masao Saitoh

http://www.w3.org/2001/XMLSchema#string

Setsuro Komiya

http://www.w3.org/2001/XMLSchema#string

Takeshi Imamura

http://www.w3.org/2001/XMLSchema#string

Yasumichi Inoue

http://www.w3.org/2001/XMLSchema#string

P2860

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

Smurf2 up-regulation activates telomere-dependent senescence

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

P304

35660-35667

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P31

scholarly article

P356

10.1074/JBC.M710496200

http://www.w3.org/2001/XMLSchema#string

P407

P433

51

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P478

283

http://www.w3.org/2001/XMLSchema#string

P50

P577

2008-10-16T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

18927080

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