about
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functionsOTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysisLoss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2Structural basis of substrate discrimination and integrin binding by autotaxinZinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activityUV-induced ligand exchange in MHC class I protein crystalsClass I major histocompatibility complexes loaded by a periodate triggerMechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetaseAn ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chainsOn Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in ProteasesMolecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of ImmunodominanceDrug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.Profiling proteasome activity in tissue with fluorescent probes.Applications for chemical probes of proteolytic activity.High-throughput T-cell epitope discovery through MHC peptide exchange.Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.Recombination-induced tag exchange to track old and new proteins.Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate.A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo.The first step of peptide selection in antigen presentation by MHC class I molecules.Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase.Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation.The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.Catching a DUB in the act: novel ubiquitin-based active site directed probes.Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2.Proteasome Activation by Small Molecules.Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit.Structural basis of the specificity of USP18 toward ISG15.Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies.CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib.Disease-associated prion protein oligomers inhibit the 26S proteasome.Chemical proteomics profiling of proteasome activity.Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib.Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing.Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets.Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition.
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description
academisch docent
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հետազոտող
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P1960
60UhHhMAAAAJ
P21
P31
P4012
P496
0000-0002-0068-054X
P569
1973-12-18T00:00:00Z
P570
2020-05-19T00:00:00Z