A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo.
about
Coordination programming of photofunctional moleculesIncorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like SitesUbiquitin proteasome dysfunction in human hypertrophic and dilated cardiomyopathiesActivity-based protein profiling of protein tyrosine phosphatasesThe ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionAssessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probesNature of pharmacophore influences active site specificity of proteasome inhibitors.Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicityActivity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5tProteasome functional insufficiency in cardiac pathogenesis.Regulation of immunoproteasome function in the lung.Design and Synthesis of Activity-Based Probes and Inhibitors for Bleomycin Hydrolase.Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells.Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity.PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection.Structure- and function-based design of Plasmodium-selective proteasome inhibitorsApplication of activity-based probes to the study of enzymes involved in cancer progression.Protein quality control and degradation in cardiomyocytes.Activity-based imaging probes of the proteasome.Activity-based probes as a tool for functional proteomic analysis of proteases.Improved quenched fluorescent probe for imaging of cysteine cathepsin activity.Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment.Irreversible inhibitors and activity-based probes as research tools in chemical glycobiology.Probes for activity-based profiling of plant proteases.Proteasome inhibitors: an expanding army attacking a unique target.Synthesis and pharmacology of proteasome inhibitors.Peptide-based proteasome inhibitors in anticancer drug design.A bright approach to the immunoproteasome: development of LMP2/β1i-specific imaging probes.The Increasing Impact of Activity-Based Protein Profiling in Plant Science.Global proteome analysis identifies active immunoproteasome subunits in human platelets.Activity-based probes for the multicatalytic proteasome.From covalent glycosidase inhibitors to activity-based glycosidase probes.Cigarette smoke induces endoplasmic reticulum stress response and proteasomal dysfunction in human alveolar epithelial cells.Triple bioorthogonal ligation strategy for simultaneous labeling of multiple enzymatic activities.Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib.A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer.Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane.In vivo imaging and biochemical characterization of protease function using fluorescent activity-based probes.Mining the Active Proteome of Arabidopsis thaliana.
P2860
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P2860
A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo.
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A fluorescent broad-spectrum p ...... teasomes in vitro and in vivo.
@ast
A fluorescent broad-spectrum p ...... teasomes in vitro and in vivo.
@en
A fluorescent broad-spectrum p ...... teasomes in vitro and in vivo.
@nl
type
label
A fluorescent broad-spectrum p ...... teasomes in vitro and in vivo.
@ast
A fluorescent broad-spectrum p ...... teasomes in vitro and in vivo.
@en
A fluorescent broad-spectrum p ...... teasomes in vitro and in vivo.
@nl
prefLabel
A fluorescent broad-spectrum p ...... teasomes in vitro and in vivo.
@ast
A fluorescent broad-spectrum p ...... teasomes in vitro and in vivo.
@en
A fluorescent broad-spectrum p ...... teasomes in vitro and in vivo.
@nl
P2093
P50
P1476
A fluorescent broad-spectrum p ...... teasomes in vitro and in vivo.
@en
P2093
Adrianus M C H van den Nieuwendijk
Celia R Berkers
Christa J Maynard
Dmitri V Filippov
Fijs W B van Leeuwen
Gijs A van der Marel
Martin D Witte
Michiel A Leeuwenburgh
Tanja Hofmann
Wouter A van der Linden
P304
P356
10.1016/J.CHEMBIOL.2006.09.013
P50
P577
2006-11-01T00:00:00Z