Disease-associated prion protein oligomers inhibit the 26S proteasome.
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Replacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell deathSustained translational repression by eIF2α-P mediates prion neurodegenerationThe ubiquitin proteasome system in neuropathologyThe concept of translocational regulationPrions--not your immunologist's pathogenThe ubiquitin-proteasome system and cardiovascular diseaseNeuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment.Analysis of quality control substrates in distinct cellular compartments reveals a unique role for Rpn4p in tolerating misfolded membrane proteins.Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated AutophagyThe ubiquitin-proteasome system in spongiform degenerative disordersParkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunctionE2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicitySolvent microenvironments and copper binding alters the conformation and toxicity of a prion fragmentChanges in proteasome structure and function caused by HAMLET in tumor cells.Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration.Cytoplasmic prion protein induces forebrain neurotoxicityTDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions.Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegenerationMethionine sulfoxides on prion protein Helix-3 switch on the alpha-fold destabilization required for conversion.Dendritic cell-mediated-immunization with xenogenic PrP and adenoviral vectors breaks tolerance and prolongs mice survival against experimental scrapie.The ubiquitin-proteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington's disease.Aging is not associated with proteasome impairment in UPS reporter mice.Context dependent neuroprotective properties of prion protein (PrP).Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress.Oligomers of mutant glial fibrillary acidic protein (GFAP) Inhibit the proteasome system in alexander disease astrocytes, and the small heat shock protein alphaB-crystallin reverses the inhibition.Cytosolic PrP can participate in prion-mediated toxicityThe ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionMetabolism of minor isoforms of prion proteins: Cytosolic prion protein and transmembrane prion proteinAggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress.N-terminal domain of prion protein directs its oligomeric association.Proteomics analysis of amyloid and nonamyloid prion disease phenotypes reveals both common and divergent mechanisms of neuropathogenesisMechanisms of In Vivo Ribosome Maintenance Change in Response to Nutrient Signals.Evaluating age-associated phenotypes in a mouse model of protein dyshomeostasis.The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis.Prion protein biosynthesis and its emerging role in neurodegeneration.Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry
P2860
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P2860
Disease-associated prion protein oligomers inhibit the 26S proteasome.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Disease-associated prion protein oligomers inhibit the 26S proteasome.
@en
type
label
Disease-associated prion protein oligomers inhibit the 26S proteasome.
@en
prefLabel
Disease-associated prion protein oligomers inhibit the 26S proteasome.
@en
P2093
P50
P1433
P1476
Disease-associated prion protein oligomers inhibit the 26S proteasome.
@en
P2093
Anthony R Clarke
Derek E Dimcheff
Fijs W B van Leeuwen
Heike Naumann
John Collinge
John L Portis
Mark Kristiansen
P304
P356
10.1016/J.MOLCEL.2007.04.001
P50
P577
2007-04-01T00:00:00Z