Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. - Test2 - elhamkhani - TriplyDB

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.

http://www.wikidata.org/entity/Q30540353

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Nanoscale histone localization in live cells reveals reduced chromatin mobility in response to DNA damage.High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling Assessing histone demethylase inhibitors in cells: lessons learned.FACT is a sensor of DNA torsional stress in eukaryotic cells.Cracking the cytotoxicity code: apoptotic induction of 10-acetylirciformonin B is mediated through ROS generation and mitochondrial dysfunction Doxorubicin, DNA torsion, and chromatin dynamics.Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction.Chemical profiling of the genome with anti-cancer drugs defines target specificities.Drugs acting on homeostasis: challenging cancer cell adaptation.Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.Transcription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspective Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast LincRNA-p21 acts as a mediator of ING1b-induced apoptosis.Unravelling the genomic targets of small molecules using high-throughput sequencing.Elucidating Compound Mechanism of Action by Network Perturbation Analysis.High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility.Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation A simple gene set-based method accurately predicts the synergy of drug pairs Stressors alter intercellular communication and exosome profile of nasopharyngeal carcinoma cells.Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy.Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosis Effect of YH0618 soup on chemotherapy-induced toxicity in patients with cancer who have completed chemotherapy: study protocol for a randomized controlled trial.A role for epigenetics in the formation of chromosome translocations in acute leukemia.Targeting FOSB with a cationic antimicrobial peptide, TP4, for treatment of triple-negative breast cancer.Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss.Transcription-generated torsional stress destabilizes nucleosomes.High expression of microRNA-454 is associated with poor prognosis in triple-negative breast cancer.Recent advances in biocompatible nanocarriers for delivery of chemotherapeutic cargoes towards cancer therapy.Topoisomerase-mediated chromosomal break repair: an emerging player in many games.Tousled-like kinase 2 regulates recovery from a DNA damage-induced G2 arrest.The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis.Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance.Synthesis of marmycin A and investigation into its cellular activity.DNMT3A in Leukemia.Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment.Monitoring the effects of doxorubicin on 3D-spheroid tumor cells in real-time.

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Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.

http://www.wikidata.org/entity/Q30540353

description

2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Drug-induced histone eviction ...... peutic effects of doxorubicin.

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Drug-induced histone eviction ...... peutic effects of doxorubicin.

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Drug-induced histone eviction ...... peutic effects of doxorubicin.

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Drug-induced histone eviction ...... peutic effects of doxorubicin.

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Drug-induced histone eviction ...... peutic effects of doxorubicin.

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Drug-induced histone eviction ...... peutic effects of doxorubicin.

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Nature Communications

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Drug-induced histone eviction ...... peutic effects of doxorubicin.

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Jeroen Janssen

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Marja Nieuwland

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Olaf van Tellingen

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Peter Huijgens

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Xiaohang Qiao

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Crystal structure of the nucleosome core particle at 2.8 A resolution

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

A decade of exploring the cancer epigenome - biological and translational implications

Targeting DNA topoisomerase II in cancer chemotherapy

Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide

Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

FACT prevents the accumulation of free histones evicted from transcribed chromatin and a subsequent cell cycle delay in G1.

Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139

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10.1038/NCOMMS2921

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4

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Jacques Neefjes

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Lennert Janssen

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236957480

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3674280

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