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Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9Crystal structure of the complex between the F(ab)' fragment of the cross-neutralizing anti-HIV-1 antibody 2F5 and the F(ab) fragment of its anti-idiotypic antibody 3H6Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding siteCrystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design ImplicationsStructural constraints imposed by the conserved fusion peptide on the HIV-1 gp41 epitope recognized by the broadly neutralizing antibody 2F5Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon AntagonismA Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan ShieldStructure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing EpitopeComputational design of high-affinity epitope scaffolds by backbone grafting of a linear epitopeRational HIV Immunogen Design to Target Specific Germline B Cell ReceptorsBroadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding GlycansSupersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120Ebolavirus VP35 Coats the Backbone of Double-Stranded RNA for Interferon AntagonismCrystal Structure of a Soluble Cleaved HIV-1 Envelope TrimerCryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope TrimerThe Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV AntibodiesStructural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.The structural basis of modified nucleosome recognition by 53BP1Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV EnvImmunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing EpitopesA next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodiesHIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimersStructure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopyBroad neutralization coverage of HIV by multiple highly potent antibodiesRedesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot LysisA Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure.Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers.Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori.CD4-induced activation in a soluble HIV-1 Env trimer.Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex.Structural evolution of glycan recognition by a family of potent HIV antibodies.A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene.Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer.Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane.HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens.Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers.
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description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Jean-Philippe Julien
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Jean-Philippe Julien
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Jean-Philippe Julien
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Jean-Philippe Julien
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Jean-Philippe Julien
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Jean-Philippe Julien
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Jean-Philippe Julien
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Jean-Philippe Julien
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Jean-Philippe Julien
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Jean-Philippe Julien
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prefLabel
Jean-Philippe Julien
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Jean-Philippe Julien
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Jean-Philippe Julien
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Jean-Philippe Julien
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Jean-Philippe Julien
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P106
P1153
14007899500
P21
P31
P496
0000-0001-7602-3995