Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes - Test2 - elhamkhani - TriplyDB

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

http://www.wikidata.org/entity/Q28271300

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HIV Genome-Wide Protein Associations: a Review of 30 Years of Research Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G Hepatitis C virus Broadly Neutralizing Monoclonal Antibodies Isolated 25 Years after Spontaneous Clearance Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Current views on the potential for development of a HIV vaccine.Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.Lessons learned from human HIV vaccine trials.A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure.Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates The core domain of hepatitis C virus glycoprotein E2 generates potent cross-neutralizing antibodies in guinea pigs HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies.Probing the Impact of Local Structural Dynamics of Conformational Epitopes on Antibody Recognition.Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV's Envelope Protein on Viral Replication in Cell Culture Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction.Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor HIV-host interactome revealed directly from infected cells.Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds.Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques.Epitope-Independent Purification of Native-Like Envelope Trimers from Diverse HIV-1 Isolates.Optimal immunization cocktails can promote induction of broadly neutralizing Abs against highly mutable pathogens.Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop.Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.Progress toward active or passive HIV-1 vaccination.Native-like Env trimers as a platform for HIV-1 vaccine design.Ontogeny-based immunogens for the induction of V2-directed HIV broadly neutralizing antibodies.Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers.An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability.Molecular Architecture of the Cleavage-Dependent Mannose Patch on a Soluble HIV-1 Envelope Glycoprotein Trimer.Regulation of Subunit-Specific Germinal Center B Cell Responses to the HIV-1 Envelope Glycoproteins by Antibody-Mediated Feedback.Breaching peripheral tolerance promotes the production of HIV-1-neutralizing antibodies.Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes.Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein Approaches to the induction of HIV broadly neutralizing antibodies.Evolution of B cell analysis and Env trimer redesign.Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem.

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Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

http://www.wikidata.org/entity/Q28271300

description

2015 nî lūn-bûn

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2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Immunogenicity of Stabilized H ...... e of Non-neutralizing Epitopes

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Immunogenicity of Stabilized H ...... e of Non-neutralizing Epitopes

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Immunogenicity of Stabilized H ...... e of Non-neutralizing Epitopes

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Immunogenicity of Stabilized H ...... e of Non-neutralizing Epitopes

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Immunogenicity of Stabilized H ...... e of Non-neutralizing Epitopes

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Immunogenicity of Stabilized H ...... e of Non-neutralizing Epitopes

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Immunogenicity of Stabilized H ...... e of Non-neutralizing Epitopes

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Immunogenicity of Stabilized H ...... e of Non-neutralizing Epitopes

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Immunogenicity of Stabilized H ...... e of Non-neutralizing Epitopes

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J.CELL.2015.11.056

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Immunogenicity of Stabilized H ...... e of Non-neutralizing Epitopes

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Alba Torrents de la Peña

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Andrew B Ward

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Anila Yasmeen

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Celia LaBranche

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Dirk Eggink

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Gabriel Ozorowski

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Hansi Dean

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Heather Arendt

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Ilja Bontjer

http://www.w3.org/2001/XMLSchema#string

Joanne DeStefano

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.

Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env

Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers

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1702-15

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scholarly article

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10.1016/J.CELL.2015.11.056

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7

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163

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Jean-Philippe Julien

Hanneke Schuitemaker

Ian Andrew Wilson

David C Montefiori

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2015-12-17T00:00:00Z

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290202014

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26687358

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4732737

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