WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling - Test2 - elhamkhani - TriplyDB

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

http://www.wikidata.org/entity/Q28485498

about

Development of anticancer agents targeting the Wnt/β-catenin signaling Stem cell guidance through the mechanistic target of rapamycin Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4 Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease Human Sarcoma growth is sensitive to small-molecule mediated AXIN stabilization.ABC transporters in CSCs membranes as a novel target for treating tumor relapse.Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer.Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2 Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells.New insights into the regulation of Axin function in canonical Wnt signaling pathway.Joint inhibition of TOR and JNK pathways interacts to extend the lifespan of Brachionus manjavacas (Rotifera).Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.Tankyrases as drug targets.Regulation of Wnt/β-catenin signaling by posttranslational modifications Tankyrases: structure, function and therapeutic implications in cancer.Recent advances in the structure-based rational design of TNKSIs.Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders.lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal.The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines.Targeting Tankyrase to Fight WNT-dependent Tumours.Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.A Cell Model Suitable for a High-Throughput Screening of Inhibitors of the Wnt/β-Catenin Pathway Identification of Novel Target for Osteosarcoma by Network Analysis

P2860

Q26781898-7D4E75B4-6DB0-4091-834A-7160BE337390 Q26795544-85DEDA07-172A-42A1-B3A0-78AEE419BB37 Q27678604-C54078CE-0C9B-45D2-BB8A-ADC524C4045A Q28078703-D7A01C65-B549-4447-B754-EAD6B128CC83 Q28085715-10EBCD07-5E96-48AD-8647-3C14D9E18CCA Q33633231-8D309F06-9B16-48FE-8855-C96B2528D3C6 Q33879326-B5F77466-E91C-4890-BDC0-F5C50800F9F7 Q35813917-1E94BFFC-0476-4C30-BDD7-1E69BD4953C1 Q35869295-6EAA2EF2-10BA-4139-A547-9BD9183A3CC9 Q37066468-596C688E-B512-4323-A99F-2D5748D63344 Q37348939-DDCC177A-1F2A-4107-988E-E05939F6AF3C Q37666459-C50BE1B0-8200-4E9B-A791-4E93260A9AAC Q37675687-1584A8D9-B86A-44D3-A775-2807C29207EE Q37712074-47CDF477-DB1F-49F0-9A5B-DC25CDC3E277 Q38104494-35712361-FA0D-40A7-AD01-3CA7D0A270B3 Q38193259-D761DA92-6F02-484F-ADC3-EFF8E72818E7 Q38224266-AC92D7F2-8439-4200-82E8-8B0BF3FCB3A2 Q38248320-DED8FCA4-B8A6-4975-BD61-050C654A7657 Q38607849-E4A5E69D-8CD2-408C-B881-7F683CD0DAA2 Q38767528-3F28A1A6-145A-4520-8D83-4AF895FDCB29 Q39036272-F57EB269-4EFE-4615-B00E-DAC635C20C9F Q39216658-65BC3910-6A84-42DF-80D2-F3D5335FF742 Q47131999-416273B9-3A33-4ABB-B89D-2C56C05D115F Q58573287-68DCE51F-4182-49F9-95BC-886EBC87E142 Q58702864-914CA6E9-AC55-4F87-B090-CDAF5A51557F

P2860

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

http://www.wikidata.org/entity/Q28485498

description

2012 nî lūn-bûn

@nan

2012 թուականին հրատարակուած գիտական յօդուած

@hyw

2012 թվականին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

name

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

@ast

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

@en

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

@nl

type

label

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

@ast

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

@en

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

@nl

prefLabel

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

@ast

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

@en

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

@nl

P1433

Q28485498-B657C409-34D6-45DC-B33F-922DB4B91973

P1476

Q28485498-7C2156FE-7069-4194-821D-358FC0F552A0

P2093

Q28485498-2AFAA17C-4617-4B3C-AD84-290307514284

Q28485498-3AAE6DFC-A5AC-4D3A-966C-E9EC3686C966

Q28485498-62014DA3-B612-45AF-95DF-6026A1A7290E

Q28485498-74AD16D1-ED36-4004-806E-AA889098EEE2

Q28485498-85129645-8B89-4DF5-B8FB-5A5203FD5251

Q28485498-967481ED-6E39-4402-ADC2-A728B43B279A

Q28485498-B6306045-3762-4945-AF58-7E1D610C0CE2

Q28485498-F79E7D06-437A-4451-9AF1-2974CC42B9EB

Q28485498-F805AE25-DB46-4C19-A3EE-1F919A7F67BC

P2860

Q28485498-08C5D5B9-61B0-4A60-A98E-0D48A9AD53AB

Q28485498-0C99EA64-38DF-4B39-B5D0-0CBF01285E4A

Q28485498-0E4A104C-315A-4C8F-8382-29B171455022

Q28485498-0FBEA2FE-2F5A-40BF-8ADE-313BB9793518

Q28485498-121F1749-B98D-474B-902C-8701115F177B

Q28485498-12FF8981-8E6B-4DEB-9A66-A25AA59CC5B0

Q28485498-2E666EBA-B96E-408A-B3D6-8398E787C6C8

Q28485498-2F119A7E-D636-4DCC-B545-D58C6FFE8DD1

Q28485498-2FCE1220-F160-4FB6-9A6E-CE9357DDFFDA

Q28485498-3C4C45EF-9E59-4304-ABFB-B25E152642BD

P304

Q28485498-E2FF08B5-8DF9-4385-8227-05F5BEF3BB8C

P31

Q28485498-C6191B10-7589-46D2-8711-F1DB255C5B19

P3181

Q28485498-21E2D98E-7BC6-488B-9FF5-D4DF057D86CB

P356

Q28485498-F45C686E-F68F-4809-AF3F-50A49B5AC61D

P407

Q28485498-6178D9A6-41E1-4CB3-A949-95E3D960B3B7

P433

Q28485498-2ABCF130-7E10-4806-929C-2E205B75D7DC

P478

Q28485498-9C69A1FE-4442-43C1-9DCE-2A2D8361B4EA

P50

Q28485498-0D259BF2-107C-4D6E-8D6D-8CAE01F547CB

Q28485498-2A239B07-7904-46AA-93AF-312DA5EACE4D

P577

Q28485498-6595C6B6-678A-47E0-A28C-315D430837A5

P5875

Q28485498-A6E5FBE9-9174-4606-AE54-71A46338B9D8

P698

Q28485498-0A8DD4E0-48BD-4DFD-99D8-081899E19D5D

P932

Q28485498-7FA449E8-DAA2-4A0D-A8C8-8F6E43E406DF

P3181

P356

JOURNAL.PONE.0050457

P1433

P1476

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

@en

P2093

Katherine A Bosch

http://www.w3.org/2001/XMLSchema#string

Kathryn C Davidson

http://www.w3.org/2001/XMLSchema#string

Kerry Fowler

http://www.w3.org/2001/XMLSchema#string

Nathan D Camp

http://www.w3.org/2001/XMLSchema#string

Nicholas C Robin

http://www.w3.org/2001/XMLSchema#string

Richard G James

http://www.w3.org/2001/XMLSchema#string

Russell J Taylor

http://www.w3.org/2001/XMLSchema#string

Timothy J Martins

http://www.w3.org/2001/XMLSchema#string

Travis L Biechele

http://www.w3.org/2001/XMLSchema#string

P2860

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

Wnt/beta-catenin signaling: components, mechanisms, and diseases

Wnt/β-catenin signaling and disease

GSK-3-selective inhibitors derived from Tyrian purple indirubins

ZINC--a free database of commercially available compounds for virtual screening

A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.

Wnt/beta-catenin signaling in development and disease

P304

e50457

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

3749179

http://www.w3.org/2001/XMLSchema#string

P356

10.1371/JOURNAL.PONE.0050457

http://www.w3.org/2001/XMLSchema#string

P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P50

Randall T. Moon

Michael B. Major

P577

2012-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

233889802

http://www.w3.org/2001/XMLSchema#string

P698

23227175

http://www.w3.org/2001/XMLSchema#string

P932

3515623

http://www.w3.org/2001/XMLSchema#string