Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma
about
A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liverThe interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage.Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cellsDisruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.Immune response and immunopathology during toxoplasmosiscPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatisPathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTPIIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondiiEvolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune CellsInactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infectionIIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerizationKEGG orthology-based annotation of the predicted proteome of Acropora digitifera: ZoophyteBase - an open access and searchable database of a coral genome.p47 GTPases regulate Toxoplasma gondii survival in activated macrophages.Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system.Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cellsThe IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP.The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartmentsIRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteinsRapid elimination of Toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signalingThe immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens.IFN-inducible GTPases in host cell defensePathogen-endoplasmic-reticulum interactions: in through the out door.SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load.IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens.The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding.Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families.TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite.Balance of Irgm protein activities determines IFN-gamma-induced host defenseToxoplasma gondii and the Immunity-Related GTPase (IRG) resistance system in mice: a review.IFN-inducible p47 GTPases display differential responses to Schistosoma japonicum acute infection.Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer.Comparative genomic analysis of eutherian interferon-γ-inducible GTPases.Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy.Pathogenesis of Chagas disease: time to move on.A New Role Discovered for IGTP: The Protective Effect of IGTP in ICH-Induced Neuronal Apoptosis.Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides.A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells.
P2860
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P2860
Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma
description
1996 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1996
@ast
im August 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/08/23)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/08/23)
@nl
наукова стаття, опублікована в серпні 1996
@uk
name
Identification of a novel GTPa ...... n response to interferon gamma
@ast
Identification of a novel GTPa ...... n response to interferon gamma
@en
Identification of a novel GTPa ...... n response to interferon gamma
@nl
type
label
Identification of a novel GTPa ...... n response to interferon gamma
@ast
Identification of a novel GTPa ...... n response to interferon gamma
@en
Identification of a novel GTPa ...... n response to interferon gamma
@nl
prefLabel
Identification of a novel GTPa ...... n response to interferon gamma
@ast
Identification of a novel GTPa ...... n response to interferon gamma
@en
Identification of a novel GTPa ...... n response to interferon gamma
@nl
P2093
P356
P1476
Identification of a novel GTPa ...... n response to interferon gamma
@en
P2093
D. A. Largaespada
G. A. Taylor
G. F. Vande Woude
M. Jeffers
N. A. Jenkins
N. G. Copeland
P304
20399–20405
P356
10.1074/JBC.271.34.20399
P407
P577
1996-08-23T00:00:00Z