Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection
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Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell deathIFN-gamma-inducible Irga6 mediates host resistance against Chlamydia trachomatis via autophagyMycobacteria in Crohn’s disease: how innate immune deficiency may result in chronic inflammationDisruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.Immune response and immunopathology during toxoplasmosisCoordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuolecPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatisUse and abuse of dendritic cells by Toxoplasma gondiiIdentification of the microsporidian Encephalitozoon cuniculi as a new target of the IFNγ-inducible IRG resistance systemMAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in miceThe polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levelsA Toxoplasma gondii pseudokinase inhibits host IRG resistance proteinsRegulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondiiInduction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondiiInactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivoIIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerizationSequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibilityThe gamma interferon (IFN-gamma)-inducible GTP-binding protein IGTP is necessary for toxoplasma vacuolar disruption and induces parasite egression in IFN-gamma-stimulated astrocytesRegulation of macrophage motility by Irgm1The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.The impact of parietal cells on Helicobacter pylori tropism and host pathology: an analysis using gnotobiotic normal and transgenic mice.Modeling infectious disease in mice: co-adaptation and the role of host-specific IFNgamma responses.Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence.The mouse resistance protein Irgm1 (LRG-47): a regulator or an effector of pathogen defense?The role of the activated macrophage in clearing Listeria monocytogenes infectionp47 GTPases regulate Toxoplasma gondii survival in activated macrophages.Host genetic susceptibility, dysbiosis, and viral triggers in inflammatory bowel disease.Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cellsThe IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infectionsInterferon-inducible effector mechanisms in cell-autonomous immunity.Dendritic cells as effector cells: gamma interferon activation of murine dendritic cells triggers oxygen-dependent inhibition of Toxoplasma gondii replicationCrohn disease: a current perspective on genetics, autophagy and immunityThe function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartmentsEtiology of Crohn's disease: many roads lead to autophagy.The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.Interferon-γ restricts Toxoplasma gondii development in murine skeletal muscle cells via nitric oxide production and immunity-related GTPases.Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes.
P2860
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P2860
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection
description
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im Juli 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/07/16)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/07/16)
@nl
наукова стаття, опублікована в липні 2001
@uk
مقالة علمية (نشرت في 16-7-2001)
@ar
name
Inactivation of LRG-47 and IRG ...... les in resistance to infection
@ast
Inactivation of LRG-47 and IRG ...... les in resistance to infection
@en
Inactivation of LRG-47 and IRG ...... les in resistance to infection
@nl
type
label
Inactivation of LRG-47 and IRG ...... les in resistance to infection
@ast
Inactivation of LRG-47 and IRG ...... les in resistance to infection
@en
Inactivation of LRG-47 and IRG ...... les in resistance to infection
@nl
prefLabel
Inactivation of LRG-47 and IRG ...... les in resistance to infection
@ast
Inactivation of LRG-47 and IRG ...... les in resistance to infection
@en
Inactivation of LRG-47 and IRG ...... les in resistance to infection
@nl
P2093
P2860
P3181
P356
P1476
Inactivation of LRG-47 and IRG ...... les in resistance to infection
@en
P2093
C. M. Collazo
G. A. Taylor
G. D. Sempowski
G. F. Vande Woude
K. C. Lusby
L. Tessarollo
P2860
P304
P3181
P356
10.1084/JEM.194.2.181
P407
P577
2001-07-16T00:00:00Z