Aurora-A kinase is essential for bipolar spindle formation and early development
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SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activityNon-centrosomal TPX2-Dependent Regulation of the Aurora A Kinase: Functional Implications for Healthy and Pathological Cell DivisionPreclinical Childhood Sarcoma Models: Drug Efficacy Biomarker Identification and ValidationAurora kinase A in gastrointestinal cancers: time to targetDNA damage associated with mitosis and cytokinesis failureAurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindleHuman Nek7-interactor RGS2 is required for mitotic spindle organization.Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle AssemblyEssential role for a novel population of binucleated mammary epithelial cells in lactation.Conditional Aurora A deficiency differentially affects early mouse embryo patterningAurora kinase-A deficiency during skin development impairs cell division and stratificationAllosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.Coordinating cellular events during spermatogenesis: a biochemical modelAurora kinases: novel therapy targets in cancersAurora A contributes to p150(glued) phosphorylation and function during mitosisInitial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP).Mitotic chromosomal instability and cancer: mouse modelling of the human disease.The aurora kinases in cell cycle and leukemiaThe Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidyIdentification of regulators of polyploidization presents therapeutic targets for treatment of AMKLKUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity.DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B.Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation.Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly.Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer.Biophysics of mitosisAurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.Regulation of embryonic and induced pluripotency by aurora kinase-p53 signalingA cyclin-dependent kinase inhibitor, dinaciclib in preclinical treatment models of thyroid cancer.Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2.Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase.SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.Comparative transcriptome analysis reveals a regulatory network of microRNA-29b during mouse early embryonic development.ENMD-2076 for hematological malignancies.Phosphorylation of NuMA by Aurora-A kinase in PC-3 prostate cancer cells affects proliferation, survival, and interphase NuMA localization.Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation.Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA
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P2860
Aurora-A kinase is essential for bipolar spindle formation and early development
description
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Februar 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/02/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/02/01)
@nl
наукова стаття, опублікована в лютому 2009
@uk
مقالة علمية (نشرت في فبراير 2009)
@ar
name
Aurora-A kinase is essential for bipolar spindle formation and early development
@ast
Aurora-A kinase is essential for bipolar spindle formation and early development
@en
Aurora-A kinase is essential for bipolar spindle formation and early development
@nl
type
label
Aurora-A kinase is essential for bipolar spindle formation and early development
@ast
Aurora-A kinase is essential for bipolar spindle formation and early development
@en
Aurora-A kinase is essential for bipolar spindle formation and early development
@nl
prefLabel
Aurora-A kinase is essential for bipolar spindle formation and early development
@ast
Aurora-A kinase is essential for bipolar spindle formation and early development
@en
Aurora-A kinase is essential for bipolar spindle formation and early development
@nl
P2093
P2860
P921
P3181
P356
P1476
Aurora-A kinase is essential for bipolar spindle formation and early development
@en
P2093
Dale O. Cowley
E. D. Salmon
Jaime A. Rivera-Pérez
Mark Schliekelman
Ryan O'Quinn
Terry Magnuson
Trudy G. Oliver
Yizhou Joseph He
P2860
P304
P3181
P356
10.1128/MCB.01062-08
P407
P577
2009-02-01T00:00:00Z