Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
about
AID and APOBECs span the gap between innate and adaptive immunityAncient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3GHuman CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombinationActivation-induced cytidine deaminase auto-activates and triggers aberrant gene expressionOptimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decayAID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.Somatic hypermutation of the AID transgene in B and non-B cellsThe structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationHoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutationEssential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytesStructure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3GShhh! Silencing by microRNA-155Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC familyActivation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseActivation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediateSecret sharers in the immune system: a novel RNA editing activity links switch recombination and somatic hypermutationIdentification of RNA editing sites in the SNP databaseAssociations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review)Antibody Affinity Maturation in Fishes-Our Current UnderstandingThe APOBEC3 family of retroelement restriction factorsRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationThe role of innate APOBEC3G and adaptive AID immune responses in HLA-HIV/SIV immunized SHIV infected macaquesMSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sitesActivation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editaseSnaps and mends: DNA breaks and chromosomal translocationsAID/APOBEC deaminases and cancerRNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeTGF-β triggers HBV cccDNA degradation through AID-dependent deaminationDNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retrovirusesARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editingAID mutates E. coli suggesting a DNA deamination mechanism for antibody diversificationFirst AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodiesAID targeting: old mysteries and new challengesActivation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogrammingBase excision repair
P2860
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P2860
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
description
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im Juni 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/06/25)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/06/25)
@nl
наукова стаття, опублікована в червні 1999
@uk
name
Specific expression of activat ...... ily in germinal center B cells
@ast
Specific expression of activat ...... ily in germinal center B cells
@en
Specific expression of activat ...... ily in germinal center B cells
@nl
type
label
Specific expression of activat ...... ily in germinal center B cells
@ast
Specific expression of activat ...... ily in germinal center B cells
@en
Specific expression of activat ...... ily in germinal center B cells
@nl
prefLabel
Specific expression of activat ...... ily in germinal center B cells
@ast
Specific expression of activat ...... ily in germinal center B cells
@en
Specific expression of activat ...... ily in germinal center B cells
@nl
P2093
P3181
P356
P1476
Specific expression of activat ...... ily in germinal center B cells
@en
P2093
K. Kinoshita
M. Muramatsu
N. O. Davidson
V. S. Sankaranand
P304
18470–18476
P3181
P356
10.1074/JBC.274.26.18470
P407
P577
1999-06-25T00:00:00Z