Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
about
Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor.hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damageDeficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stressEsc4/Rtt107 and the control of recombination during replication.microRNA-34a promotes DNA damage and mitotic catastrophe.Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1Differential regulation of centrosome integrity by DNA damage response proteins.53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in miceThe complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks.The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.Give me a break, but not in mitosis: the mitotic DNA damage response marks DNA double-strand breaks with early signaling eventsTying the loose ends together in DNA double strand break repair with 53BP1.Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End JoiningDNA double-strand break repair is impaired in presenescent Syrian hamster fibroblastsDynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.Linking abnormal mitosis to the acquisition of DNA damage53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosisAn oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks.A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis.Image-predicated sorting of adherent cells using photopatterned hydrogelsPolo-like kinase 1 inhibits DNA damage response during mitosis.γH2AX foci on apparently intact mitotic chromosomes: not signatures of misrejoining events but signals of unresolved DNA damageRegulatory cross-talk determines the cellular levels of 53BP1 protein, a critical factor in DNA repair.A New Mode of Mitotic Surveillance.Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint.DNA damage signaling in response to double-strand breaks during mitosis.The spindle assembly checkpoint regulates the phosphorylation state of a subset of DNA checkpoint proteins in Saccharomyces cerevisiaeAurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis.53BP1: keep an eye on merotelyBoundaries and physical characterization of a new domain shared between mammalian 53BP1 and yeast Rad9 checkpoint proteins.53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process.
P2860
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P2860
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
description
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
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im Januar 2002 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2002/01/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/01/01)
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наукова стаття, опублікована в січні 2002
@uk
مقالة علمية (نشرت عام 2002)
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name
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
@ast
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
@en
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
@nl
type
label
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
@ast
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
@en
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
@nl
prefLabel
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
@ast
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
@en
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
@nl
P2093
P3181
P1476
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis
@en
P2093
Denis Jullien
Paola Vagnarelli
Yasuhisa Adachi
P3181
P407
P577
2002-01-01T00:00:00Z