An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
about
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adductsMethylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaksDNA mismatch repair: molecular mechanism, cancer, and ageingMSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instabilityMutS inhibits RecA-mediated strand transfer with methylated DNA substrates.PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cellsMolecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesisManipulation of DNA Repair Proficiency in Mouse Models of Colorectal CancerStructural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesDNA replication fidelity and cancerLocalization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase INovel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.Mismatch repair proteins are activators of toxic responses to chromium-DNA damage.Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agentsGenotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families.Loss of DNA mismatch repair imparts a selective advantage in planarian adult stem cells.Differential effects of cisplatin and MNNG on dna mutants of Escherichia coli.Cellular responses to Cisplatin-induced DNA damage.Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic ResponseO6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.Making sense of missense in Lynch syndrome: the clinical perspectivePhosphorylated hMSH6: DNA mismatch versus DNA damage recognition.Mouse models of inherited cancer syndromesAnimal models of colitis-associated carcinogenesis.Mismatch and base excision repair proficiency in murine embryonic stem cellsApoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20QMajor differences between tumor and normal human cell fates after exposure to chemotherapeutic monofunctional alkylatorMolecular devices for high fidelity of DNA replication and gene expression.Trypanosoma cruzi MSH2: Functional analyses on different parasite strains provide evidences for a role on the oxidative stress response.Mismatch repair during homologous and homeologous recombinationUNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complexMismatch-mediated error prone repair at the immunoglobulin genes.Biochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D)DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapyMolecular signaling mechanisms of apoptosis in hereditary non-polyposis colorectal cancer
P2860
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P2860
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
description
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Januar 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/01/15)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/01/15)
@nl
наукова стаття, опублікована в січні 2004
@uk
مقالة علمية (نشرت في 15-1-2004)
@ar
name
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
@ast
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
@en
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
@nl
type
label
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
@ast
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
@en
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
@nl
prefLabel
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
@ast
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
@en
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
@nl
P2093
P3181
P1433
P1476
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
@en
P2093
Alan B. Clark
Diana P. Lin
Elena Avdievich
Martin Lipkin
Naoto Kurihara
Raju Kucherlapati
Stefan J. Scherer
P304
P3181
P356
10.1158/0008-5472.CAN-03-2957
P407
P577
2004-01-15T00:00:00Z